目的 了解各期哮喘患儿痰液嗜酸细胞阳离子蛋白(ECP)，可溶性白细胞介素2受体(sIL-2R)，白细胞介素5(IL-5)和免疫球蛋白E(lgE)水平，并探讨其相关性和临床意义。方法 取哮喘患儿及健康对照组痰液，以CAP系统检测ECP，用双抗体夹心ELl5A法测IL-5，sIL-2R和IgE。结果 ECP，IgE，IL-5和sIL-2R水平发作期均高于缓解期和正常对照组，相关分析显示IL-5分别与sIL-2R和ECP呈正相关，slL-2R分别与ECP和IgE呈正相关。结论 ECP，IgE，IL-5和sIL-2R均参与了哮喘炎症的形成，痰液中各指标能敏感地反映气道炎症状态，可用于监测哮喘患儿病情变化，指导临床抗炎治疗，尤以ECP和sIL-2R更敏感。

Objective To determine sputum ECP, IL-5, sIL-2R and IgE levels in children with asthma in different stages and investigate their correlation and clinical significance.Methods The sputa were obtained from children with asthma and normal control children.The concentration of ECP was assayed with pharmacia CAP system; IL-5, sIL-2R and IgE levels were measured with double-antibody ELISA technique. Results Levels of ECP, IL-5,sIL-2R and IgE in sputum during acute attack stage were significantly higher than those in remission stage and group normal control.The level of IL-5 in sputum positively correlated with that of sIL-2R and ECP respectively. The level of sIL-2R in sputum positively correlated with that of ECP and IgE respectively.Conclusions This findings suggest that all of four indices are involved in formation of airway inflammation. Their concentrations in sputum are sensitive to reflect changes of airway inflammation, and serves as safe and practical indices of monitoring the severity of disease and conducting anti-inflammation treatment,especially, ECP and sIL-2R are more sensitive.