目的 探讨内皮素(ET)与表皮生长因子(EGF)在新生儿肺炎发病中的作用和临床意义。方法 应用放免法测定38例新生儿肺炎患儿血浆ET及26例患儿尿EGF水平。结果 肺炎急性期血浆ET及尿EGF水平均明显高于对照组(P值均<0<01)；8例重症新生儿肺炎，恢复期血浆ET及尿EGF水平较急性期明显下降（P值均<0.01）。血浆ET与尿EGF水平在病程中的变化规律一致，两者呈正相关关系(r=0.481，P<0.05)。结论 ET和EGF对新生儿肺炎的发生发展可能有一定的促进作用，测定血浆ET及尿EGF可作为判断新生儿肺炎病情变化的参考指标。

Objective To investigate the pathogenic effects and clinical significance of endothelin(ET) and epidermal growth factor(EGF) levels in neonates with pneumonia. Methods The levels of plasma ET and urine EGF were determined by radioimmunoassay in 38 and 26 neonates with pneumonia respectively.Results The levels of plasma ET and urine EGF were significantly higher in the acute stage of pneumonia neonates group than those in the control group ( P <0.01). The levels of ET and EGF were significantly higher in 8 severe cases in acute stage than those in convalescent stage ( P <0.01).The changes of plasma ET were compatible with that of urine EGF in the disease process,and there was a positive correlation between them. Conclusions The results suggested that ET and EGF might have a stimulating effect on the pathogenic course of neonatal pneumonia, and the detection of ET and EGF might be considered as an estimative reference to the prognosis of neonatal pneumonia.