目的 观察实验性感染性脑水肿时β-内啡肽（β-EP）活性的变化及阿片肽受体拮抗剂金尔伦（JEL）对其影响。方法 采用兔百日咳菌液感染性脑水肿模型，观察生理盐水组（NS, n=7）、百日咳菌液组（PB，n=7）及金尔伦治疗组（JEL，n=7）3组兔脑组织含水量、伊文思蓝含量及大脑皮层、海马、血浆和脑脊液中β-EP变化。结果 PB组兔脑含水量、伊文思蓝含量显著高于NS组（P﹤0.01），血浆、脑脊液及大脑皮层、海马β-EP分别为106.33±24.96ng/ml，2.49±0.66 ng/ml，56.28±11.66ng/mg，85.97±33.76 ng/mg，均显著高于NS组（43.80±19.63ng/ml，1.14±0.39ng/ml，18.50±2.01ng/mg，22.52±6.09 ng/mg，P值均﹤0.01）；而JEL组血浆、脑脊液及大脑皮层、海马β-EP分别为69.38±4.67mg/ml, 1.44±0.26ng/ml, 31.16±7.01ng/mg, 45.03±9.98 ng/mg，均较PB组显减低（P值均﹤0.01）。结论 β-内啡肽在感染性脑水肿发生中起重要作用，金尔伦可有效地减轻脑水肿并降低β-EP活性。

Objective To better understand the potential role of β-endorphin (β-EP) in the pathogenesis of infection brain edema(IBE) , the present study was to investigate the changes of β-EP and the influence of Jinerlun, a β-EP blocker, on a rabbits model of IBE. Methods Experimental IBE was induced by pertussis bacilli in rabbits. Tweenty-one rabbits were divided randomly into three groups:①Normal saline group (NS, n =7),②Pertussis bacilli group (PB,n=7) and ③Jinerlun group (JEL, n =7) . Water content(WC),Evans Blue concentration (EB) in brain tissue and β-EPwere measured in plasma,cerebrospinal fluid(CSF),cortex and hippocampus in three groups respectively. Results WC and EB were significantly higher in the PB group than those in the NS group and JEL group ( P <0.01).β-EP of the plasma , CSF , cortex and hippocampus were significantly higher in the PB group than those in the NS group (106.33±24.96 ng/ml vs 43.80±19.63 ng/ml, 2.49±0.66 ng/ml vs 1.14±0.39 ng/ml, 56.28±11.66 ng/mg vs 18.50±2.01 ng/mg, 85.97±33.76 ng/mg vs 22.52±6.09 ng/mg, P <0.01, respectively) and in the JEL group (106.33±24.96 ng/ml vs 69.38±4.67 mg/ml, 2.49±0.66 ng/ml vs 1.44±0.26 ng/ml, 56.28±11.66 ng/mg vs 31.16±7.01 ng/mg, 85.97±33.76 ng/mg vs 45.03±9.98 ng/mg, P <0.01, respectively). Conclusions β-EP involves in the pathophysiologic processes of the experimental IBE, and Jinerlun plays an important role in amelioration of β-EP increase and IBE.