目的　观察抗胆碱能受体阻滞剂在儿童哮喘治疗中的作用及肺功能呼气峰流速 (PEFR)的变化。方法　用溴化异丙托品联合沙丁胺醇雾化吸入治疗儿童支气管哮喘急性发作 (n =1 1 ) ,而对照组单用沙丁胺醇吸入治疗 (n =9) ,并监测PEFR的变化。结果　治疗组加用溴化异丙托品后 40 ,6 0 ,80min的PEFR值 (占预计值的百分比 )分别为 6 8.8± 5 .6 % ;72 .0± 3.4% ,71 .1± 3.7% ,与单用沙丁胺醇的PEFT值 6 0 .6± 5 .7% ,6 0 .8± 6 .3% ,5 9.1± 6 .7%比较有显著性差异 (均P <0 .0 1 )。结论　溴化异丙托品与沙丁胺醇联合应用 ,其肺功能改善程度较单用沙丁胺醇更明显 ,扩张支气管作用时间更长 ,副作用少。

Objective To asses the effect of anticholinergic agent on the treatment of child asthma and to study the changes in peak expiratory flow rate (PEFR). Methods In the treatment group ipratropium bromide and salbutamol were combined to treat asthmatic children suffering from an acute attack (n=11), while in the control group only salbutamol by inhalation was used (n=9). The changes in PEFR ipratropium were measured. Results After the administration of ipratropium bromide to the treatment group, the percentage of seperately measured PEFR compared to the predicted PEFR were 68.8±5.6%, 72.0±3.4% and 71.1±3.7% after 40, 60 and 80 minutes, respectively. However, the percentages of the control group were 60.6±5.7%, 60.8±6.3% and 59.1 ± 6.7% . There was a significant difference between the two groups (P<0.01). Conclusions Combined ipratropium bromide and salbutamol by inhalation in the treatment of child asthma results in significant improvement in pulmonary function, longer lasting time of bronchodilatory effect and less side effect than salbutamol alone.