目的：探讨新生儿败血症患儿血中降钙素原(procalcitonin PCT)的改变。方法：以放免方法检测24例新生儿败血症患儿血中PCT的改变，同时检测20例缺血缺氧性脑病(HIE)以及16例正常足月儿作为正常对照。结果：新生儿败血症患儿在急性期PCT较正常对照组明显升高［(112.23±10.13) μg/L vs (8.65±2.14) μg/L］, (P<0.01)；经抗生素治疗1周后降至正常水平(9.15±3.19) μg/L vs (8.63±2.96) μg/L，(P>0.05)；而HIE组患儿PCT与正常对照组比较无明显的差别。结论：新生儿败血症患儿在急性期血中PCT明显增高,对败血症的早期诊断有一定的价值。

OBJECTIVE: To study the changes of serum procalcitonin (PCT) in neonates with sepsis. METHODS: Serum PCT was determined using an immunoradiometric assay in 20 newborn infants with neonatal sepsis, 24 neonates with hypoxicischemic encephalopathy (HIE) and 16 healthy newborn controls. RESULTS: Increased levels of serum PCT were found in neonates with sepsis compared with the control group ［(112.23±10.13) μg/L vs (8.65±2.14) μg/L］, (P<0.01). After 1 week of treatment with appropriate antibiotics, PCT levels returned to normal. There was no difference between HIE neonates and the control group. CONCLUSIONS: Elevated serum PCT levels are noted in neonatal sepsis. PCT might be of value in the diagnosis of neonatal sepsis.