OBJECTIVE: To investigate the value of cardiac troponin I (cTnI) compared with creatine kinase isoenzymes (CK-MB) in the diagnosis and progress of myocarditis in children. METHODS: Serum samples from 38 children with viral myocarditis, 24 children with non myocarditis disease and 22 healthy controls were examined for cTnI by the rapid immunochromatographic test and CK-MB was examined by enzymatic velocity analysis. CVB1-6 IgM was determined using ELISA. RESULTS: The positive rates of cTnI and CK-MB in the myocarditis group were 89.5% and 60.5%, which were significantly higher than those in the nonmyocarditis group (8.3% and 29.2% respectively) and healthy control group (0) (P<0.05). 82.4% of positive cTnI occurred within one week of the onset. There were no differences in the positive rates of cTnI and CK-MB between the CVB1-6 IgM positive group and the negative one. CONCLUSIONS: The sensitivity and specificity of cTnI in the diagnosis of myocardial injury are superior to the CK-MB test and the diagnostic window of cTnI may be wider. cTnI appears to be an excellent new clinical marker for the diagnosis and the evaluation of prognosis of myocarditis."/>
血清心脏肌钙蛋白I对小儿病毒性心肌炎诊断和转归监测价值
Abstract：OBJECTIVE: To investigate the value of cardiac troponin I (cTnI) compared with creatine kinase isoenzymes (CK-MB) in the diagnosis and progress of myocarditis in children. METHODS: Serum samples from 38 children with viral myocarditis, 24 children with non myocarditis disease and 22 healthy controls were examined for cTnI by the rapid immunochromatographic test and CK-MB was examined by enzymatic velocity analysis. CVB1-6 IgM was determined using ELISA. RESULTS: The positive rates of cTnI and CK-MB in the myocarditis group were 89.5% and 60.5%, which were significantly higher than those in the nonmyocarditis group (8.3% and 29.2% respectively) and healthy control group (0) (P<0.05). 82.4% of positive cTnI occurred within one week of the onset. There were no differences in the positive rates of cTnI and CK-MB between the CVB1-6 IgM positive group and the negative one. CONCLUSIONS: The sensitivity and specificity of cTnI in the diagnosis of myocardial injury are superior to the CK-MB test and the diagnostic window of cTnI may be wider. cTnI appears to be an excellent new clinical marker for the diagnosis and the evaluation of prognosis of myocarditis.
TIAN Jie,ZHU Jing,ZHANG Yu-Mei et al. Evaluation of the Effect of Cardiac Troponin I on the Diagnosis and Progress of Viral Myocarditis in Children[J]. CJCP, 2001, 3(5): 506-508.
