目的：观察人胎脑有无Nestin阳性细胞存在及其发育。方法：收集胎龄为16～32周不等的自愿终止妊娠引产的正常胚胎15例。应用HE染 色和免疫细胞化学方法观察不同胎龄的人胎脑脑室管膜下区、海马、纹状体的Nestin阳性细 胞。结果：分别在胎龄16周、17周、20+3周、22周、23周、24+ 5 周、25周和27周的胎脑上述3个部位中发现有数量不等的Nestin阳性表达细胞，且呈现两 种不同形态。结论：人胎脑的脑室管膜下区、海马、纹状体存在Nestin阳 性表达细胞，且呈两种不同形态。

OBJECTIVE: To understand if there are positive nestin cells in the embryonic human brain. METHODS: Fifteen normal embryoes with gestational ages of 16-32 weeks due to termination of pregnancy were enrolled in this study. The cells from hippocampus, striatum and ependyma in the embryonic human brain were studied using HE staining and immunocytochemistry. RESULTS: Different amounts of positive nestin cells were found in the hippocampus, striatum and under ependyma of the embryonic human brain with gestational age of 16 w, 17 w, 20 +3 w, 22 w, 23 w, 24 +5 w, 25 w and 27 w respectively. The positive nestin cells were displayed two different types in morphology, more in small round form than in big oval shap one. CONCLUSIONS: There are positive nestin cells, with two different forms, in the embryonic human brain.