目的　应用 β2 受体激动剂治疗的急性毛细支气管炎效果一直有争议。该研究观察毛细支气管炎患儿喘乐宁雾化吸入治疗前后肺功能的变化 ,并探讨其临床意义。方法　 30例急性毛细支气管炎患儿随机分为治疗组 1 6例 (喘乐宁雾化吸入 )和对照组 1 4例 (生理盐水雾化吸入 ) ,在雾化吸入前、吸入后即刻、1 5min和 30min分别测定潮气呼吸流速容量环 (TBFV)、呼吸系统静态顺应性及阻力的变化。结果　治疗组到达潮气呼气峰流速时呼出气量 /潮气量 (%V PF)在吸入后 30min与吸入前比较 ,差异有显著性 (P <0 .0 5 )。两组雾化后即刻 2 5 /PF、吸气时间 (Ti)差异有显著性 (P <0 .0 5 )。结论　喘乐宁雾化吸入后 30min可明显降低小气道阻力 ,改善通气。

The efficacy of β 2 agonist in the treatment of bronchiolitis has been questioned. This study aims to explore the changes of pulmonary function in infants with acute bronchiolitis before and after treatment with nebulized salbutamol. Methods Thirty infants with bronchiolitis were randomly assigned into a Treatment group (nebulized salbutamol, 0.15 mg/kg in 2 ml normal saline; n=16) and a Control group (2 ml normal saline; n=14). Tidal breathing flow volume (TBFV) loops and static respiratory system compliance (Crs) and resistance (Rrs) were measured before nebulization and immediately after nebulizer treatment, and 15 minutes and 30 minutes after treatment. Results A significant improvement in the percentage of tidal volume to peak tidal expiratory flow (%V/PF) was found in the treatment group 30 minutes after nebulization (0.184±0.05 vs 0.13±0.04; P< 0.05 ). Terminal flows/peak expiratory flow (25/PF) and peak tidal expiratory flow (PTEF) of the Treatment group also tended to improve, but there were no differences. There were also significant differences in 25/PF and inspiratory time (Ti) immediately after nebulization between the two groups. Conclusions Salbutamol treatment appears to improve peripheral airway resistance and ventilation in children with acute bronchiolitis.