Abstract：Objective To study the changes of serum and cerebrospinal fluid (CSF) levels of neuron-specific enolase (NSE), S-100β protein (S-100β) and myelin basic protein (MBP) in children with epilepsy (EP) after seizures, so as to evaluate their significance in early diagnosis of neuronal damage. Methods The serum and CSF levels of NSE, S-100β and MBP in children with EP (EP group, including 12 cases of frenquent seizures, 13 infrenquent seizures and 6 status epilepticus) were determined respectively by electrochemiluminescence and enzyme-linked immunosorbent assay within 24 hrs after seizures. Samples were obtained from thirty-eight children with upper respiratory infection and these were used as the Control group. Results The serum and CSF levels of NSE and S-100β in the EP group within 24 hrs after seizures were significantly higher than those in the Control group (P< 0.01). Of the EP group, the serum and CSF levels of NSE and S-100β in children with frenquent seizures and children with status epilepticus were significantly higher than in children with infrenquent seizures (P< 0.05 and P< 0.01, respectively), while there were no significant differences between the children with frenquent seizures and ones with status epilepticus. There were no statistically significant differences in serum and CSF MBP levels between the EP and Control groups. Conclusions NSE and S-100β in serum and CSF may be markers of neuronal damage following seizures, while MBP is not correlated with neuronal damage.
LI Guang-Qian,LIN Zhong-Dong,JIAO Ying et al. Changes of serum and cerebrospinal fluid neron2specif ic enolase , S2100βand myel in basic protein levels in children with epilepsy af ter seizures[J]. CJCP, 2004, 6(6): 500-503.
