目的：表皮生长因子与胎儿器官发育和功能成熟密切相关,该研究探讨早产儿窒息及早产儿坏死性小肠结肠炎患儿血清中表皮生长因子含量及其临床意义。方法：采用放射免疫方法检测10例足月新生儿和35例早产儿生后血清表皮生长因子浓度。结果：35～37周和28～34周早产儿血清表皮生长因子含量0.617±0.22μg/L,0.540±0.31μg/L明显低于足月新生儿0.723±0.18μg/L,差异有显著性(P<0.01);窒息早产儿与足月儿相比血清表皮生长因子水平降低更为明显0.446±0.24μg/Lvs0.723±0.18μg/L;坏死性小肠结肠炎早产儿与足月儿比较血清表皮生长因子浓度没有明显降低0.771±0.44μg/Lvs0.723±0.18μg/L,差异无显著性。结论：血清表皮生长因子水平与胎龄有关;窒息可使表皮生长因子水平降低。

Objective To evaluate the levels and clinical significance of serum epidermal growth (EGF) in premature infants.Methods Serum EGF concentrations of 10 full-term and 35 premature infants were measured by radio-immunoassay (RIA ) within 24hrs after birth.Results The serum EGF concentrations in premature infants born between 35 and 37 weeks of gestation(0.617±0.22 μg/L)and those born between 28 and 34 weeks of gestation(0.540±0.31 μg/L)were significantly lower than those in full-term infants(0.723±0.18 μg/L)( P<0.01). The asphyxiated premature infants showed a much lower EGF level(0.446±0.24 μg/L) compared with the full-term infants. The EGF concentration of the premature infants with necrotizing enterocolitis was not significantly different from that of the full-term infants. Conclusions The serum EGF concentration is associated with the gestational age. Asphyxia may result in a decreased EGF level.