目的：气道闭合压(P0.1)、呼出气末二氧化碳(PetCO2)在小儿非肺源性呼吸衰竭机械通气中的临床价值研究报道甚少。为此,该研究在这方面做一探讨。方法：对于收住儿童ICU的呼吸衰竭机械通气的患儿,监测P0.1,PetCO2。结果：P0.1在成功撤机时与上呼吸机第1天比较差异均有显著性,各年龄组0岁～,1岁～,3～16岁数据依次如下:1.8±0.25cmH2O,2.0±0.27cmH2O,2.1±0.28cmH2O。呼出气末二氧化碳(PetCO2)与动脉血二氧化碳(PaCO2)有显著正相关(r=0.894,P<0.001)。结论：在机械通气中,通过检测P0.1,PetCO2的动态变化,可了解患者的病情变化,指导呼吸机参数的调节;为临床小儿呼吸机的成功撤离提供了有关肺功能的预测指标。

OBJECTIVE: Airway occlusion pressure at 0.1 sec (P_ 0.1) has been widely used in the assessment of respiratory function. This study aimed to assess the values of P_ 0.1 and end-expiratory CO_2 (PetCO_2) in pediatric patients with mechanical ventilation. METHODS: A total of 29 mechanical-ventilation children, aged ranging from 8 months to 16 years(average of 4.3 years), with non-pulmonary respiratory failure admitted to the intensive care unit were included in this study. P_ 0.1 and PetCO_2 were monitored during mechanical ventilation. RESULTS: P_ 0.1 obtained on the day of weaning from the respirator increased significantly compared with that on the first day in the 0- 1 years old group (1.8±0.25 cmH_2O vs 0.23±0.17 cmH_2O),the 1- 3 years old group (2.0±0.27 cmH_2O vs 0.13±0.10 cmH_2O ) and the 3-16 years old group ( 2.1±0.28 cmH_2O vs 0.30±0.17 cmH_2O) (P< 0.001). PetCO_2 positively correlated with PaCO_2 (r= 0.894, P< 0.001). CONCLUSIONS: Monitoring the changes of P_ 0.1 and PetCO_2 is useful in adjusting the parameters of the respirator during mechanical ventilation. P_ 0.1 may serve as a marker for weaning from mechanical ventilation.