目的：该研究探讨1~48月健康婴幼儿肺功能的各项指标。方法：将295名1~48月的健康婴幼儿分成7组：1~2月、3~4月、5~7月、8~12月、13～24月、25~36月、37~48月组。用美国森迪公司2600型儿童肺功能仪测定肺功能值，以潮气流速容量曲线部分替代最大呼气流速容量曲线，检测反映部分通气功能指标；被动呼气流速容量技术，测定呼吸系统阻力和顺应性；以及开放式氮气洗出法测定功能残气量。结果：呼吸频率（RR）随年龄增加而减少。潮气量（TV）随年龄而增加。潮气呼气峰流速（PTEF）随年龄增加而增加。呼气时间/总呼吸时间（Ti/Tt）、呼出气量/潮气量（%V-PF）、呼气流速/潮气呼气峰流速（25/PF），在各年龄组差异均无显著性。潮气呼气中期流速/潮气吸气中期流速（ME/MI）：在1~12月组间比较差异有显著性(P<0.01)。在13~48月组间比较差异无显著性。潮气呼气峰流速/潮气量（PF/Ve） 1~12月组间差异有显著性(P<0.01)，而13~48月组间比较差异无显著性。总气道阻力（Rrs）随年龄增加而逐渐减少。呼吸系统静态顺应性（Crs）随年龄增加而逐渐增加，Crs/kg在1~12月组间比较差异有显著性（P<0.01）；而13~48月组间比较差异无显著性。功能残气量（FRC）随年龄增加逐渐增加（P<0.01），而FRC/kg组间比较差异无显著性。结论：该实验各项数据能寻求到一定的规律，可以为观察呼吸系统疾患时肺功能的变化情况提供参考。

OBJECTIVE: To study the development of pulmonary function of healthy children between 1- 48 months.METHODS: A total of 295 healthy children at ages of 1- 48 months were classified into 7 groups according to their age, i.e., 1-2 months, 3- 4 months, 5-7 months, 8-12 months, 13-24 months, 25-36 months, and 37- 48 months. Pediatric pulmonary function laboratory type 2600 (Sensor Medics Corporation USA) was used to detect tidal flow volume curve, which can partially replace the maximum expiratory flow volume curve and reflect airway ventination function. Passive expiratory flow volume technique was used to examine respiratory system static compliance and total airway resistance. Open nitrogen washout method was used to measure functional residual capacity. RESULTS: The values of tidal, peak tidal expiratory flow, and respiratory system static compliance functional residual capacity increased with the increasing age and were significantly different among the 7 groups. However, respiratory rate and total airway resistance decreased with the increased age. The value of each parameter of tidal flow volume curve was stable during 1-48 months.CONCLUSIONS: This study displayed the developmental characteristics of pulmonary function of healthy children at ages of 1-48 months, which is useful to observe the changes of pulmonary function in respiratory diseases.