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| 轮状病毒感染和细胞因子相关性研究进展 |
| 夏群，陈兰举 |
| 蚌埠医学院第一附属医院儿科，安徽蚌埠233400 |
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| Research advance in the association between rotavirus infection and cytokines |
| XIA Qun, CHEN Lan-Ju |
| Deportment of Pediatrics, First Affiliated Hospital of Bengbu Medical University, Anhui, Bengbu 233400, China |
| ［1］李建军，刘作义. 细胞因子与婴幼儿轮状病毒肠炎的关系［J］.实用儿科临床杂志, 2003,18(7):533-534.
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| ［2］齐铁雄，谢立新，王永祥，王军民，陈惠兰，周立智.轮状病毒肠炎患儿血清和大便 IL-2、IL-6、IFN-γ动态变化与临床指标关系的研究［J］.中华实验和临床病毒学杂志, 2002, 16(3):270-273.
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| ［3］Bass DM. Interferon gamma and interleukin 1, but not interferon alfa, inhibit rotavirus entry into human intestinal cell lines［J］.Gastroenterology, 1997, 113（1）:81-89.
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| ［4］Vancott JL, Franco MA, Greenberg HB, Sabbaj S, Tang B, Murray R, et al. Protective immunity to rotavirus shedding in the absence of interleukin6: Th1 cells and immunoglobulin a develop normally［J］.J Virol , 2000, 74(11):5250-5256.
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| ［5］Sestak K, McNeal MM, Choi A, Cole MJ, Ramesh G, Alvarez X, et al. Defining T-cell-mediated immune responses in rotavirus-Infected juvenile rhesus macaques［J］. J Virol, 2004, 78(19):10258-10264.
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| ［6］Azevedo M, Yuan L, Pouly S, Gonzales A, Jeong K, Nguyen T, et al.Cytokine responses in gnotobiotic pigs after infection with virulent or attenuated human rotavirus［J］. J Virol, 2006, 80(1):372-382.
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| ［7］Casola A, Garofalo RP, Crawford SE, Estes MK, Mercurio F, Croweet SE, et al. Interleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus:role of viral-induced IκB kinase activation［J］.Virology, 2002, 298(1): 8-19.
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| ［8］Jiang B, Snipes-Magaldi L, Dennehy P, Keyserling H, Holman RC, Bresee J, et al. Cytokines as mediators for or effectors against rotavirus disease in children［J］. Clin Diagn Lab Immunol, 2003, 10(6):995-1001.
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| ［9］Monteleone G, Parrello T, Monteleone I, Tammaro S, Luzza F, Palloneet F. Interferon-gamma (IFNγ) and prostaglandin E2 (PGE2) regulate differently IL-12 production in human intestinal lamina propria mononuclear cells (LPMC)［J］.Clin Exp Immunol, 1999, 117（3）:469-475.
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| ［10］僧靖静，周建华，刘长江，高铁铮.轮状病毒肠炎 IL-12 的变化及意义［J］.中国免疫学杂志, 2002, 22(12):868-870.
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| ［11］Narvaez CF, Angel J, Franco MA. Interaction of rotavirus with human myeloid dendritic cells［J］. J Virol, 2005, 79(23):14526-14535.
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| ［12］Azim T, Ahmad SM, Sefat-E-Khuda, Sarker MS, Unicomb LE, De S, et al. Immune response of children who develop persistent diarrhea following rotavirus infection［J］. Clin Diagn Lab Immunol, 1999, 6(5):690-695.
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| ［13］Vancott JL, McNeal MM, Choi AH, Ward RL. The role of interferons in rotavirus infections and protection ［J］.Interferon Cytokine Res, 2003, 23(3):163-170.
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| ［14］Franco MA, Tin C, Rott LS, VanCott JL, McGhee JR, Greenberg HB. Evidence for CD8+ T-cell immunity to murine rotavirus in the absence of perforin, fas, and gammainterferon［J］.J Virol,1997, 71(1):479-486.
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| ［15］VanCott JL, Prada AE, McNeal MM, Stone SC, Basu M, Huffer B, et al. Mice Develop Effective but delayed protective immune responses when immunized as neonates either intranasally with nonliving VP6/LT(R192G) or orally with live rhesus rotavirus vaccine candidates［J］. J Virol, 2006, 80(10):4949-4961.
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| ［16］Smiley KL, McNeal MM, Basu M, Choi AHC, Clements JD, Ward RL. Association of Gamma Interferon and Interleukin-17 Production in Intestinal CD4+ T cells with protection against totavirus shedding in mice intranasally immunized with VP6 and the adjuvant LT(R192G)［J］.J Virol, 2007, 81(8):3740-3748.
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| ［17］Azim T, Zaki MH, Podder G, Sultana N, Salam MA, Rahman SM, et al. Rotavirus-specific subclass antibody and cytokine responses in Bangladeshi children with rotavirus diarrhoea［J］.J Med Virol, 2003, 69(2):286-295.
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| ［18］李丽萍，袁明纯. 轮状病毒感染肠黏膜损伤与肿瘤坏死因子关系的研究［J］.中华内科杂志, 2007, 19(2):148-150.
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| ［19］吴建春,姚英明.轮状病毒胃肠炎和表皮生长因子关系初步研究［J］.世界华人消化杂志, 2003, 11(11):1793-1794.
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| ［20］Mack CL, Tucker RM, Sokol RJ, Kotzin BL.Armed CD+4 Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia［J］. Clin Immunol, 2005, 115(2):200-209.
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| ［21］Shivakumar P, Campbell KM, Sabla GE, Miethke A, Tiao G, McNeal MM, et al. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia［J］.J Clin Investigat, 2004, 114(3):322-329.
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| ［22］Tucker RM, Hendrickson RJ, Mukaida N, Gill RG, Mack CL. Progressive biliary destruction is independent of a functional tumor necrosis factor-alpha pathway in a murine model of biliary atresia［J］.Viral Immunol, 2007, 20(1):34-43.
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| ［23］Mohanty SK, Shivakumar P, Sabla G, Bezerra JA. Loss of interleukin-12 modifies the pro-inflammatory response but does not prevent duct obstruction in experimental biliary atresia ［J］. BMC Gastroenterology, 2006, 6(14):1-10.
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| ［24］Blomqvist M, Juhela S, Erkkila S, Korhonen S, Simell T, Kupila A, et al. Rotavirus infections and development of diabetes-associated autoantibodies during the first 2 years of life［J］. Clin Exp Immunol, 2002, 128(3):511-515.
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| ［25］Makela M, Oling V, Marttila J, Waris M, Knip M, Simell O, et al. Rotavirus-specific T cell responses and cytokine mRNA expression in children with diabetes-associated autoantibodies and type 1 diabetes ［J］.Clin Exp Immunol, 2006, 145(2):261-270.
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| ［26］Kawashima H, Inage Y, Ogihara M, Kashiwagi Y, Takekuma K, Hoshika A, et al. Serum and cerebrospinal fluid nitrite/nitrate levels in patients with rotavirus gastroenteritis induced convulsion［J］. Life Sci, 2004, 74(1):1397-1405.
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| ［27］张春芳.亚洲地区轮状病毒感染的流行病学概况［J］.中国当代儿科杂志，2006，8（1）79-82.
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| ［28］高有桂，金玉，柳颐龄，叶新华.轮状病毒肠炎患儿血清及粪便白细胞介素-18和干扰素-γ含量的变化及意义［J］.中国当代儿科杂志，2006，8（4）304-306.
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