目的：目前对儿童抽动-秽语综合征（TS）的治疗主要以口服药物为主，但鉴于药物的不良反应及每日1~2次口服药物不方便，导致患儿依从性差。该文探讨可乐定透皮贴剂治疗TS的临床疗效和安全性。方法：将119例5～17岁TS患儿分为两组，治疗组65例采用可乐定透皮贴剂；对照组54例给予氟哌啶醇口服。4周后观察两组的疗效。疗效评定采用耶鲁大体抽动严重程度量表（YGTSS）测定。结果贴剂治疗组YGTSS减分率（61.5±7.5）%，对照组减分率（41.0±6.3）%，两组减分率通过χ2检验差异有显著性（P<0.05）。贴剂治疗组53例有效，有效率为81.5%，对照组36例有效，有效率为67.5%，差异无显著性。贴剂治疗组1例出现血压下降、头晕反应，停药后恢复。对照组2例出现轻度的颈肌张力增高，4例出现轻度嗜睡，疲乏。结论 可乐定透皮贴剂对治疗儿童TS有明显疗效，且不良反应少而轻微，方便，易于接受。［中国当代儿科杂志，2009，11（7）：537-539］

OBJECTIVE: Children with Tourette's syndrome (TS) have a poor treatment compliance due to side effects and inconvenient administration of oral drugs. This study explored the efficacy and safety of clonidine transdermal patch for treating TS in children. METHODS: A total of 119 children with TS were randomly treated with the clonidine transdermal patch (n=65) or with oral haloperidol (n=54). The therapeutic efficacy was assessed based on the results of the Yale Global Tic Severity Scale (YGTSS) 4 weeks after treatment. RESULTS: The clonidine transdermal patch group showed a higher reduction in the overall tic symptom scores (61.5±7.5%) than that in the haloperidol group (41.0±6.3%; P<0.05). Clonidine transdermal patch treatment was effective in 53 patients (81.5%) and 36 patients (67.5%) showed effective to oral haloperidol (P>0.05). Mild side effects (decrease of blood pressure and dizziness) were observed in 1 patient in the clonidine transdermal patch group. Mild hypermyotonia, drowsiness or lassitude as side effects occurred in 6 patients in the haloperidol group. CONCLUSIONS: Clonidine transdermal patch is effective for the treatment of TS in children and its side effects are mild and rare.［Chin J Contemp Pediatr, 2009, 11 (7):537-539］