IL-13和TNF-α在肺炎支原体肺炎儿童血清中的表达及意义

郦银芳, 于莹, 陆志芳

中国当代儿科杂志 ›› 2010, Vol. 12 ›› Issue (04) : 275-277.

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中国当代儿科杂志 ›› 2010, Vol. 12 ›› Issue (04) : 275-277.
论著·临床研究

IL-13和TNF-α在肺炎支原体肺炎儿童血清中的表达及意义

  • 郦银芳,于莹,陆志芳
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Serum levels of IL-13 and TNF-α in children with Mycoplasma pneumoniae pneumonia

  • LI Yin-Fang, YU Ying, LU Zhi-Fang
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摘要

目的:观察白细胞介素13(interleukin-13,IL-13)和肿瘤坏死因子α(tumor necrosis factor alpha,TNF-α)在小儿肺炎支原体肺炎中的变化。方法:酶联免疫方法检测40例肺炎支原体肺炎伴喘息患儿、40例肺炎支原体肺炎不伴喘息患儿、其他病原菌感染肺炎40例(普通肺炎组)及40例正常对照组儿童的血清IL-13和TNF-α的浓度。结果:肺炎支原体肺炎患儿血清IL-13、TNF-α的水平高于正常对照组及普通肺炎组;肺炎支原体肺炎伴喘息患者的IL-13、TNF-α的水平分别为214.6±67.2 ng/L,0.55±0.13 ng/L,高于不伴喘息者(189.6±52.1 ng/L, 0.42±0.16 ng/mL),差异均有显著性(P<0.01)。结论:IL-13、TNF-α浓度增高可能在小儿肺炎支原体肺炎导致喘息样发作中起重要作用。[中国当代儿科杂志,2010,12(4):275-277]

Abstract

OBJECTIVE: To examine serum levels of interleukin-13 (IL-13) and tumor necrosis factor alpha (TNF-α) in children with Mycoplasma pneumoniae (MP) pneumonia. METHODS: Eighty children with MP pneumonia complicated by wheezing or without (n=40 each), 40 children with pneumonia from non-MP infection and 40 healthy children were enrolled. Serum levels of IL-13 and TNF-α were measured using ELISA. RESULTS: The serum levels of IL-13 and TNF-α in the MP pneumonia group were significantly higher than those in non-MP pneumonia group and the healthy control group (P<0.01). The children with MP pneumonia complicated by wheezing had increased serum levels of IL-13 (214.6±67.2 ng/L vs 189.6±52.1 ng/L; P<0.01) and TNF-α(0.55±0.13 ng/mL vs 0.42±0.16 ng/mL; P<0.01)compared with those without wheezing. CONCLUSIONS: The increase in serum levels of IL-13 and TNF-α may play important roles in the pathogenesis of MP pneumonia and wheezing attack in children.[Chin J Contemp Pediatr, 2010, 12 (4):275-277]

关键词

肺炎支原体肺炎 / 喘息 / 白细胞介素13 / 肿瘤坏死因子α / 儿童

Key words

Mycoplasma pneumoniae pneumonia / Wheezing / Interleukin-13 / Tumor necrosis factor alpha / Child

引用本文

导出引用
郦银芳, 于莹, 陆志芳. IL-13和TNF-α在肺炎支原体肺炎儿童血清中的表达及意义[J]. 中国当代儿科杂志. 2010, 12(04): 275-277
LI Yin-Fang, YU Ying, LU Zhi-Fang. Serum levels of IL-13 and TNF-α in children with Mycoplasma pneumoniae pneumonia[J]. Chinese Journal of Contemporary Pediatrics. 2010, 12(04): 275-277
中图分类号: R725.6   

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