多巴胺D2受体基因/ANKK1TaqIA多态性与小婴儿气质

马静; 黄春香; 皮丕湘; 夏爱斌; 苏林雁

PDF(995 KB)

中国当代儿科杂志 ›› 2010, Vol. 12 ›› Issue (2) : 106-109.

论著·临床研究

多巴胺D2受体基因/ANKK1TaqIA多态性与小婴儿气质

马静，黄春香，皮丕湘，夏爱斌，苏林雁

作者信息 +

DRD2/ANKK1 Taq IA polymorphism and early infant temperament

MA Jing, HUANG Chun-Xiang, PI Pi-Xiang, XIA Ai-Bin, SU Lin-Yan

Author information +

文章历史 +

摘要

目的：探讨多巴胺D2受体基因(DRD2)/含锚蛋白重复和激酶域 1 Taq IA基因（ANKK1Taq IA）（rs1800497）多态性与小婴儿气质是否存在关联。方法：采用聚合酶链反应连接酶检测（PCR-LDR）多态性分析技术，检测了长沙市149 名汉族婴儿的Taq IA基因多态性;用小婴儿气质问卷（EITQ）在婴儿出生后1～4月(平均年龄2.75月)时测查其气质（母亲填写）；根据TaqIA多态性等位基因片段大小分为C/C型、T/T型、C/T型。将气质类型分为含“T” 基因型组（T/T+T/C）和不含“T”基因型组（C/C）进行统计分析。结果：含“T”基因型组和不含“T”基因型组婴儿其气质类型分布差异无显著性，在气质9个维度上的得分差异均无显著性。结论：DRD2/ANKK1TaqIA多态性与小婴儿气质无相关关系。［中国当代儿科杂志，2010，12（2）：106-109］

Abstract

OBJECTIVE: To investigate whether there is an association between DRD2/ANKK1 Taq IA polymorphism and early infant temperament. METHODS: DRD2/ANKK1 Taq IA polymorphism (rs1800497) was determined using polymerase chain reaction-ligase detection reaction (PCR-LDR) techniques in 149 Chinese Han infants from Changsha City. Their mothers were asked to complete the Early Infant Temperament Questionnaires (EITQ) when the infants were 1 to 4 months old (mean: 2.75 months). There were three genotypes found in these infants: C/C, T/T and C/T. The subjects were subdivided into T-carrier (CT, TT) and non-T-carrier (CC) groups for statistical analysis. RESULTS: There were no differences in the temperament style distribution between the T-carrier and non-T carrier groups. There were also no statistically significant differences between the two groups in the score of the nine temperament dimensions. CONCLUSIONS: DRD2/ANKK1 Taq IA polymorphism is not associated with early infant temperament.［Chin J Contemp Pediatr, 2010, 12 (2):106-109］

导出引用

马静, 黄春香, 皮丕湘, 夏爱斌, 苏林雁. 多巴胺D2受体基因/ANKK1TaqIA多态性与小婴儿气质[J]. 中国当代儿科杂志. 2010, 12(2): 106-109

MA Jing, HUANG Chun-Xiang, PI Pi-Xiang, XIA Ai-Bin, SU Lin-Yan. DRD2/ANKK1 Taq IA polymorphism and early infant temperament[J]. Chinese Journal of Contemporary Pediatrics. 2010, 12(2): 106-109

中图分类号： R395.1

参考文献

［1］Saudino KJ. Behavioral genetics and child temperament［J］. J Dev Behav Pediatr, 2005, 26(3):275-286.
［2］Huang WH, Payne TJ, Ma JZ, Beuten J, Dupont RT, Inohara N, et al. Association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample［J］. Neuropsychopharmacology, 2009, 34（2）:319-330.
［3］Bergen AW, Yeager M, Welch RA, Haque K, Ganjeiet JK, van den Bree MB, et al. Association of multiple DRD2 polymorphisms with anorexia nervosa［J］. Neuropsychopharmacology, 2005, 30（9）:1703-1710.
［4］Bombin I, Arango C, Mayoral M, Castro-Fornieles J, Gon-zalez-Pinto A, Gonzalez-Gomez C, et al. DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents［J］. Am J Med Genet B Neuropsy-chiatr Genet, 2008, 147B（6）:873-879.
［5］Munafo` MR, Matheson IJ, Flint J. Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias［J］. Mol Psychiatry, 2007, 12（5）:454-461.
［6］中国行为医学科学编委会. 行为医学量表手册［M］. 北京:中华医学会电子音像出版社, 2005:54-59.
［7］向华,侯晓华.多巴胺及其受体与胃黏膜保护［J］. 世界华人消化杂志, 2003, 11(12):1997-1999.
［8］Reddy BM, Reddy ANS, Nagaraja T, Bhaskaret LVKS, Singh HP, Naidu VM, et al. Anthropological perspective of the single nucleotide polymorphisms in the NPY and DRD2 genes among the socio-economically stratified populations of Andhra Pradesh, India［J］. Int J Hum Genet, 2007, 7(4):277-284.
［9］Zuckerman M. The psychobiological model for impulsive unso-cialized sensation seeking: a comparative approach［J］. Neuropsychobiology, 1996, 34（3）:125-129.
［10］张劲松，许积德，沈理笑. Carey 的1个月～12岁儿童气质系列问卷的应用评价［J］. 中国心理卫生杂志, 2000, 14(3):153-156.
［11］Rothbart MK, Chew KH, Gartstein MA. Assessment of tempera-ment in early development［M］// Zeskind PS. Biobehavioral assessment of the infant. New York: Guilford Press, 2001:190-208.
［12］McAllister TW, Rhodes CH, Flashman LA, Mc Donald BC, Belloni D, Saykin AJ. Effect of the Dopamine D2 receptor T allele on response latency after mild traumatic brain injury［J］. Am J Psychiatry, 2005, 162（9）:1749-1751.
［13］Sander T, Ladehoff M, Samochowiec J, Finckh U, Rommelspacher H, Schmidt LG. Lack of anallelic association between polymorphisms of thedopamine D2 receptor gene and alcohol dependence in the German population［J］. Alcohol Clin Exp Res, 1999, 23（4）:578-581.
［14］Shaikh KJ, Naveen D, Murthy A, Sherrin T, Thennarasu K, Anand A, et al. Polymorphisms at the DRD2 locus in early-onset alcohol dependence in the Indian population［J］. Addict Biol, 2001, 6（4）: 331-335.
［15］Elovainio M, Jokela M, KivimaAkim M, Pulkki-Raback L, Le-htimaki T, Airla N, et al. Genetic variants in the DRD2 gene moderate the relationship between stressful life events and depressive symptoms in adults: cardiovascular risk in young finns study［J］. Psychosom Med, 2007, 69（5）:391-395.
［16］Noble EP, Ozkaragoz TZ., Ritchie TL, Zhang X, Belin TR, Sparkes RS. D2 and D4 dopamine receptor polymorphisms and personality［J］. Am J Med Genet, 1998, 81（3）:257-267.
［17］Burt SA, McGue M, Iacono W, Comings D, MacMurray J. An examination of the association between DRD4 and DRD2 polymorphisms and personality traits［J］. Pers Individ Dif, 2002, 33（6）:849-859.
［18］Nyman ES, Loukola A, Varilo T, Ekelund J, Veijola J, Joukamaa M, et al. Impact of dopamine receptor gene family on temperament traits in a population-based birth cohort［J］. Am J Med Genet B Neuropsychiatr Genet, 2009, 150B(6):854-865.
［19］Montag C, Buckholtz JW, Hartmann P, Merz M, Burk C, Hennig J, et al. COMT genetic variation affects fear processing: psychophysiological evidence ［J］. Behav Neurosci, 2008, 122(4):901-909.
［20］Wiebe SA, Espy KA, Stopp C, Respass J, Stewart P, Jameson TR, et al. Gene-environment interaction across development: exploring DRD2 genotype and prenatal smoking effects on self regulation［J］. Dev Psychol, 2009, 45(1):31-44.