烟雾病患儿粒细胞集落刺激因子的变化

马明圣; 邹丽萍; 丁瑛雪; 金洪

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中国当代儿科杂志 ›› 2010, Vol. 12 ›› Issue (2) : 117-119.

论著·临床研究

烟雾病患儿粒细胞集落刺激因子的变化

马明圣，邹丽萍，丁瑛雪，金洪

作者信息 +

Concentrations of granulocyte colony-stimulating factor in children with moyamoya disease

MA Ming-Sheng, ZOU Li-Ping, DING Ying-Xue, JIN Hong

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摘要

目的：探讨粒细胞集落刺激因子（G-CSF）在烟雾病发病机制中的作用。方法：采用酶联免疫吸附法(ELISA)检测20例有症状的烟雾病患儿及20例健康对照儿童的血清G-CSF浓度。结果：健康对照组的血清G-CSF 浓度平均值为23.5±3.8 pg/mL, 烟雾病组平均值为35.7±10.3 pg/mL。烟雾病组的血清G-CSF平均浓度明显高于健康对照组，P<0.01。结论：烟雾病组的血清G-CSF浓度比健康对照组明显升高, 提示G-CSF在烟雾病的发病机制中可能具有重要作用。［中国当代儿科杂志，2010，12（2）：117-119］

Abstract

OBJECTIVE: To explore the roles of granulocyte colony-stimulating factor in the pathogenesis of moyamoya disease. METHODS: Serum G-CSF concentrations were measured using enzyme linked immunosorbent assay (ELISA) in 20 children with moyamoya disease and 20 healthy children. RESULTS: Serum G-CSF concentration (35.7±10.3 pg/mL) in children with moyamoya disease was significantly higher than that in healthy controls (23.5±3.8 pg/mL) (P<0.01). CONCLUSIONS: The elevated serum G-CSF concentration in children with moyamoya disease suggests that G-CSF may play an important role in the pathogenesis of moyamoya disease.［Chin J Contemp Pediatr, 2010, 12 (2):117-119］

导出引用

马明圣, 邹丽萍, 丁瑛雪, 金洪. 烟雾病患儿粒细胞集落刺激因子的变化[J]. 中国当代儿科杂志. 2010, 12(2): 117-119

MA Ming-Sheng, ZOU Li-Ping, DING Ying-Xue, JIN Hong. Concentrations of granulocyte colony-stimulating factor in children with moyamoya disease[J]. Chinese Journal of Contemporary Pediatrics. 2010, 12(2): 117-119

中图分类号： R743

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