重症遗尿症药物治疗停药方式的对照研究

唐芳政; 刘亚兰; 文飞球; 张朝霞

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中国当代儿科杂志 ›› 2010, Vol. 12 ›› Issue (3) : 198-200.

论著·临床研究

重症遗尿症药物治疗停药方式的对照研究

唐芳政，刘亚兰，文飞球，张朝霞

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Comparison of therapeutic effects in severe nocturia: gradual versus immediate drug withdrawal

TANG Fang-Zheng, LIU Ya-Lan, WEN Fei-Qiu, ZHANG Zhao-Xia

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摘要

目的：探讨不同停药方式对重症遗尿症预后的影响。方法：97例重症遗尿症患儿随机分为对照组（n=47）和观察组（n=50），给予同样的药物治疗12周，但采取不同的停药方式。对照组在疗程结束后立即停药；观察组在疗程结束后行阶梯式减量。观察两组自完全停药3个月后遗尿的次数。结果：两组在治疗期间治愈率均为100%。停药3个月后对照组治愈率为60%（28人），观察组为92%（46人），治愈率差异有统计学意义（P<0.01）。两组药物副作用和患儿依从性差异无统计学意义。结论：重症遗尿症的患儿进行同样的药物治疗方案，但不同的停药方式可导致不同的预后，阶梯式减量停药方式明显优于立即停药的方式。［中国当代儿科杂志，2010，12（3）：198-200］

Abstract

OBJECTIVE: To investigate possible differences in the prognosis in children with severe nocturia who received different drug withdrawal schedules. METHODS: Ninety-seven children with severe nocturia were randomly assigned to two groups: control (n=47) and observed (n=50). The control group accepted drug withdrawal immediately, while the observed group accepted dose tapering gradually after a 12-week treatment course. The frequency of enuresis was observed three months after complete drug withdrawal. RESULTS: During the treatment, the frequency of enuresis in all of children from both the control and the observed groups was reduced by over 90%. Forty-six children (92%) from the observed group showed the frequency of enuresis was reduced by over 90%, but 28 children (60%) from the control group (P<0.01) three months after the complete drug withdrawal. There were no significant differences in the adverse effect and the medication compliance between the two groups. CONCLUSIONS: The different schedules of drug withdrawal may lead to different prognosis, and the schedule of gradual drug withdrawal may be superior to the immediate one in children with nocturnal enuresis.［Chin J Contemp Pediatr, 2010, 12 (3):198-200］

导出引用

唐芳政, 刘亚兰, 文飞球, 张朝霞. 重症遗尿症药物治疗停药方式的对照研究[J]. 中国当代儿科杂志. 2010, 12(3): 198-200

TANG Fang-Zheng, LIU Ya-Lan, WEN Fei-Qiu, ZHANG Zhao-Xia. Comparison of therapeutic effects in severe nocturia: gradual versus immediate drug withdrawal[J]. Chinese Journal of Contemporary Pediatrics. 2010, 12(3): 198-200

中图分类号： R256.54

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