Do intra-operative fluids influence the need for Post-operative cardiotropic support after a PDA ligation?

Brigitte LEMYRE, Ling LIU, Gregory Paul MOORE, Sarah Linda LAWRENCE, Nicholas J. BARROWMAN

中国当代儿科杂志 ›› 2011, Vol. 13 ›› Issue (1) : 1-7.

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中国当代儿科杂志
PDF(859 KB)
中国当代儿科杂志 ›› 2011, Vol. 13 ›› Issue (1) : 1-7.
英文论著

Do intra-operative fluids influence the need for Post-operative cardiotropic support after a PDA ligation?

  • Brigitte LEMYRE, Ling LIU, Gregory Paul MOORE, Sarah Linda LAWRENCE, Nicholas J. BARROWMAN
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Do intra-operative fluids influence the need for Post-operative cardiotropic support after a PDA ligation?

  • Brigitte LEMYRE, Ling LIU, Gregory Paul MOORE, Sarah Linda LAWRENCE, Nicholas J. BARROWMAN
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摘要

OBJECTIVE: To investigate the effect of intra-operative intravenous fluids on post-operative hemodynamic stability. METHODS: We performed a retrospective cohort study of 98 preterm infants who underwent a patent ductus arteriosus (PDA) ligation in one NICU between 2001 and 2007. The primary outcome was the need for cardiotropic support within 24 hrs of ligation. RESULTS: Twenty-seven infants (28%) required post-operative cardiotropic support. The amount of intra-operative fluids varied between 0 and 50.4 mL/kg (median: 10.2 mL/kg). No intra-operative fluid was recorded in 26 patients. Fluids were not associated with the need for post-operative cardiotropic support (P=0.10). Using a multivariate logistic regression model, age at ligation, weight at ligation and pre-operative FiO2 were significant predictors of post-operative cardiotropic support. CONCLUSIONS: Intra-operative fluids do not appear to be associated with the need for post-operative cardiotropic support. A prospective cohort study may help identify modifiable risk factors and improve outcomes in this population.

Abstract

OBJECTIVE: To investigate the effect of intra-operative intravenous fluids on post-operative hemodynamic stability. METHODS: We performed a retrospective cohort study of 98 preterm infants who underwent a patent ductus arteriosus (PDA) ligation in one NICU between 2001 and 2007. The primary outcome was the need for cardiotropic support within 24 hrs of ligation. RESULTS: Twenty-seven infants (28%) required post-operative cardiotropic support. The amount of intra-operative fluids varied between 0 and 50.4 mL/kg (median: 10.2 mL/kg). No intra-operative fluid was recorded in 26 patients. Fluids were not associated with the need for post-operative cardiotropic support (P=0.10). Using a multivariate logistic regression model, age at ligation, weight at ligation and pre-operative FiO2 were significant predictors of post-operative cardiotropic support. CONCLUSIONS: Intra-operative fluids do not appear to be associated with the need for post-operative cardiotropic support. A prospective cohort study may help identify modifiable risk factors and improve outcomes in this population.

关键词

Hemodynamics / Patent ductus arteriosus ligation / Premature infant

Key words

Hemodynamics / Patent ductus arteriosus ligation / Premature infant

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Brigitte LEMYRE, Ling LIU, Gregory Paul MOORE, Sarah Linda LAWRENCE, Nicholas J. BARROWMAN. Do intra-operative fluids influence the need for Post-operative cardiotropic support after a PDA ligation?[J]. 中国当代儿科杂志. 2011, 13(1): 1-7
Brigitte LEMYRE, Ling LIU, Gregory Paul MOORE, Sarah Linda LAWRENCE, Nicholas J. BARROWMAN. Do intra-operative fluids influence the need for Post-operative cardiotropic support after a PDA ligation?[J]. Chinese Journal of Contemporary Pediatrics. 2011, 13(1): 1-7
中图分类号： R541.1   

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