目的：了解近10年2型糖尿病（T2DM）和肥胖儿童中糖尿病（DM）前期的患病情况及T2DM的发病趋势。方法：对2000年10月至2010年9月住院且新诊断的DM以及肥胖患儿的临床资料进行回顾性分析。结果：（1）共诊断DM患儿503例，其中T2DM 31例。前后5年比较，T2DM构成比则从0.05‰上升到0.18‰（P<0.01）。与前5年相比，近5年T1DM病例数增加了1.35倍，T2DM增加了4.20倍，T2DM构成比的增长幅度大于1型糖尿病（T1DM）（P<0.05）。（2）1301例肥胖儿童接受口服葡萄糖耐量试验，其中29例确诊为T2DM，255例为DM前期。DM前期255例中，合并脂代谢紊乱133例，非酒精性脂肪肝病138例，高血压53例。结论：近5年T1DM和T2DM患病率均有明显增加，T2DM的增长快于T1DM。肥胖儿童DM前期的发生率较高，潜在发生T2DM以及心血管病变风险大。
Abstract
OBJECTIVE: To investigate the incident and prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in obese children in the last ten years. METHODS: The clinical data of hospitalized children with newly diagnosed diabetes mellitus (DM) or obesity between October 2000 and September 2010 were retrospectively studied. RESULTS: A total of 503 newly onset cases were diagnosed as DM in the past ten years, of which 31 were diagnosed as T2DM. The prevalence of T2DM in the second five-year duration increased significantly compared with that in the first five-year duration (0.18‰ vs 0.05‰; P<0.01). The number of cases of type 1 diabetes mellitus (T1DM) and T2DM increased by 1.35 fold and 4.20 fold, respectively in the second five-year duration. A total of 1301 obese patients received oral glucose tolerance tests, and 29 cases were diagnosed with T2DM and 255 cases with prediabetes. Of the 255 cases of prediabetes, 133 had dyslipidemia, 138 had non-alcoholic fatty liver disease and 53 had hypertension. CONCLUSIONS: The prevalence rates of T1DM and T2DM increased significantly in the last 5 years. The prevalence of T2DM increased more significantly than T1DM. There was a higher prevalence of prediabetes in obese children. Childhood obesity predicts a higher risk of T2DM and cardiovascular disease in the future.
关键词
2型糖尿病 /
糖尿病前期 /
肥胖 /
儿童
Key words
Type 2 diabetes mellitus /
Prediabetes /
Obesity /
Child
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