OBJECTIVE: To estimate the prevalence of attention deficit hyperactivity disorder (ADHD) in children with epilepsy, and the factors that may contribute to the prevanlence of co-morbidity between ADHD and epilepsy. METHODS: A total of 256 children aged 6-15 years old who were diagnosed with epilepsy were enrolled. The prevalence of ADHD in children with epilepsy, and the factors that may contribute to the development of co-morbidity between ADHD and epilepsy were explored. RESULTS: The systematic evaluation in 192 patients was completed. Of the 192 children, 81 (42.2%) were diagnosed with ADHD. The earlier the epilepsy onset, the higher the frequency of the co-morbidity of ADHD occurring. The longer the period of antiepileptic medication, the higher the prevalence of the co-morbidity of ADHD. Epileptic children receiving a combination of antiepileptic drugs had a higher prevalence of ADHD. ADHD was more common in children with some specific types of epilepsy, such as Lannox-Gastaut syndrome and generalized tonic-clonic epilepsy, or epilepsy with multifocal epileptic discharges in the EEG record. CONCLUSIONS: ADHD occurs frequently in children with epilepsy. The factors associated with increased risk of ADHD include the onset age of epilepsy, the types of seizures or epileptic syndromes, the epileptiform EEG discharges, and the effects of antiepileptic drugs.
HAN Ying, QIN Jiong, JIANG Yu-Wu, CHEN Jing, JI Xin-Na, LIN Qing.
Co-morbidity of attention deficit hyperactivity disorder in children with epilepsy[J]. Chinese Journal of Contemporary Pediatrics. 2012, 14(2): 89-92
中图分类号：
R749.1+7
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参考文献
［1］左启华. 小儿神经系统疾病［M］. 第2版. 北京：人民卫生出版社，2005: 4-215.
［2］Karina SL, Alysson MC, Joel AL, Jane de AN. ADHD and epilepsy: Contributions from the use of behavioral rating scales to investigate psychiatric comorbidities［J］. Epilepsy Behav, 2011, 20(3): 484-489.
［4］Reilly CJ. Attention deficit hyperactivity disorder (ADHD) in childhood epilepsy［J］. Res Dev Disabil, 2011, 32(3): 883-893.
［5］Loutfi KS, Carvalho AM, Lamounier JA, Nascimento Jde A. ADHD and epilepsy: contributions from the use of behavioral rating scales to investigate psychiatric comorbidities［J］. Epilepsy Behav, 2011, 20(3): 484-489.
［6］Sherman EM, Brooks BL, Akdag S, Connolly MB, Wiebe S. Parents report more ADHD symptoms than do teachers in children with epilepsy［J］. Epilepsy Behav, 2010, 19(3): 428-435.
［7］Wannag E, Eriksson AS, Larsson PG. Attention-deficit hyperactivity disorder and nocturnal epileptiform activity in children with epilepsy admitted to a national epilepsy center［J］. Epilepsy Behav, 2010, 18(4): 445-449.
［8］Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised clinical and electroencephalographicclassification of epileptic seizures［J］. Epilepsia, 1981, 22(4): 489-501.
［9］Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes［J］. Epilepsia, 1989, 30(4): 389-399.
［10］Leggett C, Hotham E. Treatment experiences of children and adolescents with attention-deficit/hyperactivity disorder［J］. J Paediatr Child Health, 2011, 47(8): 512-517.
［14］Shen YC, Wang YF, Yang XL. An epidemiological investigation of minimal brain dysfunction in six elementary schools in Beijing［J］. J Child Psychol Psychiatry, 1985, 26(5): 777-787.
［17］Koneski JA, Casella EB. Attention deficit and hyperactivity disorder in people with epilepsy: diagnosis and implications to the treatment［J］. Arq Neuropsiquiatr, 2010, 68(1): 107-114.
［18］Davis SM, Katusic SK, Barbaresi WJ, Killian J, Weaver AL, Ottman R, et al. Epilepsy in children with attention-deficit/hyperactivity disorder ［J］. Pediatr Neurol, 2010, 42(5): 325-330.
［19］Mahone EM, Ranta ME, Crocetti D, O′Brien J, Kaufmann WE, Denckla MB, et al. Comprehensive examination of frontal regions in boys and girls with attention-deficit/hyperactivity disorder［J］. J Int Neuropsychol Soc, 2011, 17(6): 1047-1057.
［20］Liston C, Cohen MM, Teslovich T, Levenson D, Casey BJ. Atypical prefrontal connectivity in attention-deficit/hyperactivity disorder: pathway to disease or pathological end point? ［J］. Biol Psychiatry, 2011, 69(12): 1168-1177.
［23］Bruce H, Jana J, Kevin D, Chase AA, Raj S, Jason F, et al. The frequency, complications and aetiology of ADHD in new onset paediatric epilepsy［J］. Brain, 2007, 130 (12): 3135-3148.
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