Distribution of pathogenic microorganisms and its relationship with clinical features in children with community-acquired pneumonia
SHU Lin-Hua1, XU Jiang-Jiang2, WANG Shu3, ZHONG Hai-Qin1, DONG Xiao-Yan1, JIANG Kun1, ZHANG Hui-Yan1, XIONG Qin1, WANG Chao1, SUN Ting1, SUN Chao1, LU Quan1
Department of Respiratory Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, China
Abstract：Objective To study the distribution of pathogenic microorganisms in different genders, age groups and seasons in children with community-acquired pneumonia (CAP) and the relationship between the distribution of pathogenic microorganisms and clinical features. Methods A total of 1 155 children with CAP were enrolled, among whom there were 670 boys and 485 girls, with a mean age of 3.1±2.8 years (range:one month to 14 years). Indirect immunofluorescence assay, particle agglutination test, enzyme-linked immunosorbent assay, colloidal gold method. and bacterial culture were applied to determine common respiratory pathogenic microorganisms in sputum, throat swabs, blood samples, bronchoalveolar lavage fluid, and urine. Results A total of 758 specimens (65.63%) were tested positive by pathogen detection. The top three dominant pathogens were Mycoplasma pneumoniae (MP, 43.64%), bacteria (15.12%), and respiratory syncytial virus (RSV, 9.26%), and the rate of mixed infection was 16.02%. The rates of MP infection between boys and girls with CAP were different (40.8% vs 47.6%;POR=1.747 and 1.418, respectively;both PConclusions MP plays a more and more important role in the pathogenic microorganisms of CAP in children. Prevalence and outbreaks of MP infection among children should be alerted in summer and autumn. There are differences in the detection rate of various pathogenic microorganisms in CAP children with various age groups. The clinical features of children with CAP caused by different pathogenic microorganisms are different.
SHU Lin-Hua,XU Jiang-Jiang,WANG Shu et al. Distribution of pathogenic microorganisms and its relationship with clinical features in children with community-acquired pneumonia[J]. CJCP, 2015, 17(10): 1056-1061.
Chen K, Jia R, Li L, et al. The aetiology of community associated pneumonia in children in Nanjing, China and aetiological patterns associated with age and season[J]. BMC Public Health, 2015, 15:113-118.
Kelly MS, Smieja M, Luinstra K, et al. Association of respiratory viruses with outcomes of severe childhood pneumonia in Botswana[J]. PLoS One, 2015, 10(5):e0126593.
Huong Ple T, Hien PT, Lan NT, et al. First report on prevalence and risk factors of severe atypical pneumonia in Vietnamese children aged 1-15 years [J]. BMC Public Health, 2014, 14:1304-1311.
