Department of Child Health Care, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, Jiangsu 214002, China
Abstract：Objective To study the association between overweight/obesity in parents before maternal pregnancy and the development of autism spectrum disorders (ASD) in offspring. Methods A total of 36 children who were diagnosed with ASD (ASD group) and 72 normal children matched for sex and age (control group) were enrolled. A questionnaire survey was performed to collect the general information, including body height and body weight of parents before maternal pregnancy and maternal weight gain during pregnancy. Univariate and multivariate logistic regression analyses were used to investigate the association between overweight/obesity in parents before maternal pregnancy and ASD in offspring. Results The ASD group had a significantly higher detection rate of overweight/obesity in the father than the control group (56% vs 32%; P=0.018) before maternal pregnancy. The univariate and multivariate logistic regression analyses showed that overweight/obesity of the father before maternal pregnancy was a risk factor for ASD in offspring (OR=2.66 and 2.58 respectively; P < 0.05). Conclusions Overweight/obesity of the father before maternal pregnancy is an independent risk factor for ASD in offspring, and therefore, it is important for the father to control his body mass index within the normal range before maternal pregnancy.
QIU Ting,GUO Bing-Bing,WANG Li-Zhen et al. Association between overweight/obesity in parents and autism spectrum disorders in offspring[J]. CJCP, 2018, 20(5): 383-386.
Lai MC, Lombardo MV, Baron-Cohen S. Autism[J]. Lancet, 2014, 383(9920):896-910.
[2]
Reynolds LC, Inder TE, Neil JJ, et al. Maternal obesity and increased risk for autism and developmental delay among very preterm infants[J]. J Perinatol, 2014, 34(9):688-692.
[3]
Gardner RM, Lee BK, Magnusson C, et al. Maternal body mass index during early pregnancy, gestational weight gain, and risk of autism spectrum disorders:results from a Swedish total population and discordant sibling study[J]. Int J Epidemiol, 2015, 44(3):870-883.
[4]
Bilder DA, Bakian AV, Viskochil J, et al. Maternal prenatal weight gain and autism spectrum disorders[J]. Pediatrics, 2013, 132(5):e1276-e1283.
[5]
Dodds L, Fell DB, Shea S, et al. The role of prenatal, obstetric and neonatal factors in the development of autism[J]. J Autism Dev Disord, 2011, 41(7):891-902.
[6]
Krakowiak P, Walker CK, Bremer AA, et al. Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders[J]. Pediatrics, 2012, 129(5):e1121-e1128.
[7]
Li M, Fallin MD, Riley A, et al. The association of maternal obesity and diabetes with autism and other developmental disabilities[J]. Pediatrics, 2016, 137(2):e20152206.
[8]
Wang Y, Tang S, Xu S, et al. Maternal body mass index and risk of autism spectrum disorders in offspring:a Meta-analysis[J]. Sci Rep, 2016, 6:34248.
[9]
Surén P, Gunnes N, Roth C, et al. Parental obesity and risk of autism spectrum disorder[J]. Pediatrics, 2014, 133(5):e1128-e1138.
[10]
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5)[M]. Arlington, VA:American Psychiatry Publishing, 2013:50-58.
Institute of Medicine (US) and National Research Council (US) Committee to Reexamine IOM Pregnancy Weight Guidelines; Rasmussen KM, Yaktine AL. Weight Gain During Pregnancy:Reexamining the Guidelines[M]. Washington D.C.:National Academies Press, 2009:16.
