Abstract：Objective To study the association between some factors in maternal pregnancy and childhood asthma with an onset before 3 years of age, and to provide a basis for the prevention and treatment of childhood asthma and further research on its pathogenesis. Methods A retrospective clinical epidemiological study was carried out in 100 children with asthma (age of onset <3 years) and 100 children without allergic disease who were randomly selected as controls. The related information of children and mothers was investigated by questionnaire survey, including general information, medical history, personal and family allergic history, perinatal data, and mothers' health and lifestyle during their pregnancy such as diet, disease, and environmental exposure. The main survey indices were preliminarily analyzed, selected, and assigned, and then the data were subjected to univariate and multivariate logistic regression analyses. Results The univariate and multivariate logistic regression analyses showed that the fetal sex, history of atopic disease before pregnancy, history of respiratory infection in pregnancy, and the intake of fish, shrimp, crab, meat and spicy food in pregnancy were significantly associated with childhood asthma with an onset before 3 years of age, with odds ratios of 2.868, 5.051, 4.640, 3.746, 2.971, 3.075, and 2.225, respectively. Conclusions Many factors in maternal pregnancy are associated with childhood asthma with an onset before 3 years of age, and the risk of which can be reduced by the prevention of respiratory infection and appropriate diet in pregnancy.
XU Hui-Jie,YUAN Xue-Jing. Association between some factors in maternal pregnancy and childhood asthma with an onset before 3 years of age[J]. CJCP, 2015, 17(6): 585-589.
Masoli M, Fabian D, Holt S, et al. The global burden of asthma:executive summary of the GINA Dissemination Committee Report[J]. Allergy, 2004, 59(5):469-478.
[2]
Saadeh D, Salameh P, Baldi I, et al. Diet and allergic diseases among population aged 0 to 18 years:myth or reality?[J]. Nutrients, 2013, 5(9):3399-3423.
[3]
Yong SB, Wu CC, Wang L, et al. Influence and mechanisms of maternal and infant diets on the development of childhood asthma[J]. Pediatr Neonatol, 2013, 54(1):5-11.
[4]
Chen F, Marquez H, Kim YK, et al. Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice[J]. J Clin Invest, 2014, 124(2):801-811.
[5]
Miyake Y, Tanaka K, Okubo H, et al. Maternal fat intake during pregnancy and wheeze and eczema in Japanese infants:the Kyushu Okinawa Maternal and Child Health Study[J]. Ann Epidemiol, 2013, 23(11):674-680.
[6]
Dotterud CK, Storro O, Simpson MR, et al. The impact of preand postnatal exposures on allergy related diseases in childhood:a controlled multicentre intervention study in primary health care [J]. BMC Public Health, 2013, 13:123.
Schonberger HJ, Dompeling E, Knottnerus JA, et al. Prenatal exposure to mite and pet allergens and total serum IgE at birth in high-risk children[J]. Pediatr Allergy Immunol, 2005, 16(1):27- 31.
[10]
Vance GH, Holloway JA. Early life exposure to dietary and inhalant allergens[J]. Pediatr Allergy Immunol, 2002, 13 (Suppl 15):14-18.
[11]
Prescott SL, Taylor A, Roper J, et al. Maternal reactivity to fetal alloantigens is related to newborn immune responses and subsequent allergic disease[J]. Clin Exp Allergy, 2005, 35(4):417-425.
Chandra RK. Breast feeding, hydrolysate formulas and delayed introduction of selected foods in the prevention of food hypersensitivity and allergic disease[J]. Nutr Res, 2002, 22(1):125-135.
[16]
Hughes CH, Jones RCM, Wright DE, et al. A retrospective study of the relationship between childhood asthma and respiratory infection during gestation[J]. Clin Exp Allergy, 1999, 29(10):1378-1381.
[17]
Maslova E, Hansen S, Jensen CB, et al. Vitamin D intake in mid-pregnancy and child allergic disease-a prospective study in 44,825 Danish mother-child pairs[J]. BMC Pregnancy Childbirth, 2013, 13:199.
[18]
Sewell DA, Hammersley VS, Devereux G, et al. Investigating the effectiveness of the Mediterranean diet in pregnant women for the primary prevention of asthma and allergy in high-risk infants:protocol for a pilot randomised controlled trial[J]. Trials, 2013, 14:173.
[19]
Devereux G. Maternal diet during pregnancy:an emerging risk factor for childhood asthma[J]. Expert Rev Clin Immunol, 2008, 4(6):663-668.
[20]
Romieu I, Torrent M, Garcia-Esteban R, et al. Maternal fish intake during pregnancy and atopy and asthma in infancy[J]. Clin Exp Allergy, 2007, 37(4):518-525.
[21]
Leermakers ET, Sonnenschein-van der Voort AM, Heppe DH, et al. Maternal fish consumption during pregnancy and risks of wheezing and eczema in childhood:the Generation R Study[J]. Eur J Clin Nutr, 2013, 67(4):353-359.
[22]
Willers SM, Devereux G, Craig LC, et al. Maternal food consumption during pregnancy and asthma, respiratory and atopic symptoms in 5-year-old children[J]. Thorax, 2007, 62(9):773-779.
[23]
Seyedrezazadeh E, Moghaddam MP, Ansarin K, et al. Fruit and vegetable intake and risk of wheezing and asthma:a systematic review and meta-analysis[J]. Nutr Rev, 2014, 72(7) :411-428.
[24]
Miyake Y, Tanaka K, Okubo H, et al. Dietary meat and fat intake and prevalence of rhinoconjunctivitis in pregnant Japanese women:baseline data from the Kyushu Okinawa Maternal and Child Health Study[J]. Nutr J, 2012, 11:19.
[25]
Kabesch M. Gene by environment interactions and the development of asthma and allergy[J]. Toxicol Lett, 2006, 162(1):43-48.
