目的：地方性氟中毒对病区儿童的身心发育和智力的危害已经引起了国内外学者的广泛关注，该研究旨在探讨地方性氟中毒病区高氟对儿童智力发育的影响。方法：通过计算机检索和手工检索国内外1995~2007年发表的相关文献，进行质量评价后按一定标准筛选文献，得到有关研究地方性氟中毒与儿童智力发育之间关系的符合标准的13篇文献，采用Cochrane协作网的RevMan 4．3软件进行Meta分析。结果：纳入该次Meta分析的13篇研究地方性氟中毒与儿童智力发育关系的文献中，高氟组儿童2 508例，对照组儿童2 330例，经 Meta分析一致性检验，各研究结果不同质（χ2=268.05，P<0.01），支持随机效应模式，计算的OR为-7.14,其95％CI为(-9.90，-4.37)。Meta分析提示高氟区地方性氟中毒儿童的智力发育落后于对照组儿童。结论：长期高氟摄入对病区儿童的智力发育存在一定程度的不良影响。

OBJECTIVE: To investigate the effect of high levels of fluoride on children's intelligence development by analyzing the literatures systematically. METHODS: The literatures on the relationship between endemic fluorosis and children's intelligence development published between 1995 and 2007 were retrieved electronically and manually. A total of 13 relevant literatures that met the inclusion criteria were included for Meta analysis. Meta analysis was performed using the Coorporative network software RevMan 4.3. RESULTS: The subjects of the 13 literatures included 2 508 children from the high fluoride group and 2 330 children from the control group. Meta analysis showed these literatures were inhomogenous (χ2=268.05, P<0.01). Therefore a random effect model was used. The average effect scale (OR=-7.14; 95%CI: -9.90, -4.37) suggested a negative correlation between high fluorosis exposure and children's intelligence development. CONCLUSIONS: Exposure to high levels of fluoride may adversely influence children's intelligence development.