Abstract：Objective To investigate the situation of human parvovirus B19 infection in children with various diseases in Xinjiang Province,PRC.Methods A total of 81 hospitalized children [18 cases of Henoch-Schoenlein purpura, 17 aplastic anemia (AA), 16 myocarditis, 9 idiopathic thrombocytopenic purpura (ITP), 8 acute lymphocytic leukemia, 8 respiratory infection and 5 nervous system diseases] in the First Affiliated Hospital of Xinjiang Medical University between August 2001 and December 2002 were involved in this study. Enzyme linked immunosorbent assay (ELISA) was employed to detect serum Bl9-IgM and B19-IgG. Serum samples from 16 healthy children were used as the Control group. Results Seven (41.2%) of 17 children with AA and 4 (44.4%) of 9 children with ITP were positive for B19-IgM. The positive rate for B19-IgM of children with either ITP or AA was significantly higher than that of the Control group ( 6.25%, 1/16) (both P<0.05).There were no significant differences in the positive rate for B19-IgM between the rest patients and the Control group.The positive rate for Bl9-lgG in all 81 patients was not different from the Control group.Conclusions The B19 infection rate was higher in children with ITP or AA in Xinjiang region. It is suggested that human parvovirus Bl9 may be closely related to ITP and AA.
GU Li-Na-?Sha-Ding,DUO Li-Kun-?Mu-Za-Po-Er,GUO Yan-Fang et al. Detection of specific antibodies to human parvovirus B19 in 81 children with various diseases[J]. CJCP, 2005, 7(1): 65-67.
