Abstract：Objective This study examined the colonic transit time and anorectal motor in children with constipation. Methods Twenty-eighty children with constipation (Constipation group) and 43 healthy children (Control group) were enrolled in this study.Total gastrointestinal transit time (TGITT), left colonic transit time (LCTT), right colonic transit time (RCTT) and rectosigmoid colonic transit time (RSTT) were measured by the simplified method of radiopaque makers.Meanwhile, anorectal vector manometry was performed. The Constipation group was subdivided into Slow-transit group and Normal transit group according to the TGITT to explore the value of anorectal manometry in different types of constipation. Results The TGITT, LCTT and RSTT of the Constipation group were significantly longer than those in the Control group (92±56 hrs vs 29±8 hrs, P< 0.01; 17±13 hrs vs 7±4 hrs, P< 0.01; 62±29 hrs vs 13±6 hrs, P< 0.01), while there was no significant difference in the RCTT between the two groups. Compared with that of the Control group, the anorectal maximal squeezing pressure (MaxSP) of the Constipation group was significantly higher ( 216±44 mmHg vs 190±38 mmHg, P< 0.05). In contrast,the anorectal vector symmetric index (VSI) was significantly lower (0.71±0.06 vs 0.84±0.08, P< 0.05). The anorectal vector volume (VV) was the same for the two groups. There were no significant differences in MaxSP, VV and VSI between the Slow-transit and Normal transit groups. Conclusions The colonic transit time is prolonged and anorectal dynamic disorder is present in children with constipation. Anorectal manometry is needed for any of the constipated children no matter who has normal or abnormal colonic transit time.
ZHANG Shu-Cheng,WANG Wei-Lin,BAI Yu-Zuo et al. Determination of colonic transit time and anorectal vector manometry in children with constipation[J]. CJCP, 2005, 7(1): 39-42.
