儿童幽门螺杆菌感染与白细胞介素-8含量的关系

张强英, 余咏文, 黄惠清, 李鸣

中国当代儿科杂志 ›› 2004, Vol. 6 ›› Issue (4) : 284-286.

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PDF(393 KB)
中国当代儿科杂志 ›› 2004, Vol. 6 ›› Issue (4) : 284-286.
论著

儿童幽门螺杆菌感染与白细胞介素-8含量的关系

  • 张强英,余咏文,黄惠清,李鸣
作者信息 +

Relationship between Helicobacter pylori infection and the interleukin-8 level in children

  • ZHANG Qiang-Ying, YU Yong-Wen, HUANG Hui-Qing, LI Ming
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摘要

目的:白细胞介素-8(IL-8)作为趋化因子,可引起粒细胞在局部组织聚集,介导炎症反应。该文探讨小儿幽门螺杆菌(Hp)感染与胃粘膜及血清IL-8含量的关系。方法:53例患儿进行胃镜检查,采集胃粘膜标本用快速尿素酶试验及病理组织学方法检测胃粘膜Hp,同时用双抗体夹心酶联免疫吸附试验法(ELISA)测定其胃粘膜及血清中IL-8的含量。结果:53例患儿中29例Hp阳性,24例阴性;Hp感染患儿胃粘膜中IL-8含量显著高于非Hp感染患儿,差异有显著性(P<0.01),而血清IL-8含量在Hp感染组与非Hp感染组无显著差异(P>0.05),经根治Hp治疗后,Hp感染患儿胃粘膜中IL-8含量下降,差异有显著性(P<0.01),而血清IL-8含量无显著变化(P>0.05)。结论:Hp感染可以诱导胃粘膜炎症细胞合成IL-8,IL-8在Hp相关性胃十二指肠疾病的发病机制中起着重要作用。

Abstract

OBJECTIVE: To explore the relationship between Helicobacter pylori (Hp) infection and the gastric mucosa and serum interleukin-8 (IL-8) levels in children so as to study the role of IL-8 in Hp-related gastrointestinal diseases. METHODS: Fifty-three children with recurrent upper abdominal pain or other related complaints were given endoscopy inspection. The gastric mucosa was collected for Hp qualitative detection by both rapid urea enzyme test and histopathologic examination. The gastric and serum IL-8 levels were detected using ELISA. RESULTS: Hp infection was confirmed in 29 children. The gastric IL-8 level in children with Hp infection ( 32.86± 3.92 pg/mg) was significantly higher than that of children without Hp infection ( 13.75± 2.19 pg/mg) (P< 0.01). There was no difference in serum IL-8 level between them. After the treatment of Hp infection, the gastric IL-8 level in children with Hp infection decreased significantly ( 15.91± 3.15 pg/mg) (P< 0.01), while serum IL-8 level of children with Hp infection was not different before and after treatment. CONCLUSIONS: Hp infection can induce the inflammatory cells of the gastric mucosa to secrete IL-8. IL-8 may play an important role in the pathogenesis of Hp-related gastrointestinal diseases.

关键词

幽门螺杆菌 / 白细胞介素-8 / 胃十二指肠疾病 / 儿童

Key words

Helicobacter pylori infection / Interleukin-8 / Gastroduodenal disease / Child

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导出引用
张强英, 余咏文, 黄惠清, 李鸣. 儿童幽门螺杆菌感染与白细胞介素-8含量的关系[J]. 中国当代儿科杂志. 2004, 6(4): 284-286
ZHANG Qiang-Ying, YU Yong-Wen, HUANG Hui-Qing, LI Ming. Relationship between Helicobacter pylori infection and the interleukin-8 level in children[J]. Chinese Journal of Contemporary Pediatrics. 2004, 6(4): 284-286
中图分类号: R725.7   

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