OBJECTIVE: The cause of Guillain Barre Syndrome (GBS) is still not clear. Some researchers thought that it was related to infection, especilly Campylobacter jejuni (CJ) infection. This paper aims at studying the relationship between CJ infection and Ganglioside GM 1 injury so as to explore the mechanism of GBS. METHODS: The levels of CJ IgG antibody and the antibodies of ganglioside GM 1 IgG and GM 1 IgM were detected by enzyme linked immunosorbent assay in serum or cerebrospinal fluid of 31 children with GBS. Of the 31 patients, there were 23 cases of acute inflammatory demyelinating polyradiculo neuropathy (AIDP) and 8 cases of acute motor axonal neuropathy (AMAN). Thirty three children with non GBS neurological diseases (NGBS group) and 10 normal children were used as the control groups. RESULTS: The serum CJ IgG levels in both acute and recovery phases in the AMAN group were significantly higher than those of the NGBS group (P< 0.01 ); and the serum anti CJ IgG level in the acute phase in the AIDP group also significantly increased compared with that of the NGBS group (P< 0.01 ). The CJ IgG levels in cerebrospinal fluid in acute phase in the AMAN and AIDP groups were higher than that of the NGBS group (P< 0.01 ). The serum GM 1 IgM levels in both acute and recovery phases in the AMAN and AIDP groups were higher than those of the two control groups (P< 0.05 ). The serum GM 1 IgG level was higher than that of the normal control group, but it did not differ from that of the NGBS group. There were significant differences in the GM 1 IgM level in the cerebrospinal fluid between the GBS group and the NGBS group (P< 0.05 ). CJ IgG was positively correlated to GM 1 IgG and GM 1 IgM (R= 0.722 , P= 0.05 ). CONCLUSIONS: CJ infection may be an important cause of in the development GBS. The immunological injury of ganglioside GM 1 may be related to the pathogenesis of GBS."/>
急性感染性多发性神经根炎患儿空肠弯曲菌感染与抗神经节苷脂GM_1抗体关系
Abstract：OBJECTIVE: The cause of Guillain Barre Syndrome (GBS) is still not clear. Some researchers thought that it was related to infection, especilly Campylobacter jejuni (CJ) infection. This paper aims at studying the relationship between CJ infection and Ganglioside GM 1 injury so as to explore the mechanism of GBS. METHODS: The levels of CJ IgG antibody and the antibodies of ganglioside GM 1 IgG and GM 1 IgM were detected by enzyme linked immunosorbent assay in serum or cerebrospinal fluid of 31 children with GBS. Of the 31 patients, there were 23 cases of acute inflammatory demyelinating polyradiculo neuropathy (AIDP) and 8 cases of acute motor axonal neuropathy (AMAN). Thirty three children with non GBS neurological diseases (NGBS group) and 10 normal children were used as the control groups. RESULTS: The serum CJ IgG levels in both acute and recovery phases in the AMAN group were significantly higher than those of the NGBS group (P< 0.01 ); and the serum anti CJ IgG level in the acute phase in the AIDP group also significantly increased compared with that of the NGBS group (P< 0.01 ). The CJ IgG levels in cerebrospinal fluid in acute phase in the AMAN and AIDP groups were higher than that of the NGBS group (P< 0.01 ). The serum GM 1 IgM levels in both acute and recovery phases in the AMAN and AIDP groups were higher than those of the two control groups (P< 0.05 ). The serum GM 1 IgG level was higher than that of the normal control group, but it did not differ from that of the NGBS group. There were significant differences in the GM 1 IgM level in the cerebrospinal fluid between the GBS group and the NGBS group (P< 0.05 ). CJ IgG was positively correlated to GM 1 IgG and GM 1 IgM (R= 0.722 , P= 0.05 ). CONCLUSIONS: CJ infection may be an important cause of in the development GBS. The immunological injury of ganglioside GM 1 may be related to the pathogenesis of GBS.
LI Bing,YANG Li-Bin,HUANG Tie-Shuan et al. Relationship Between Campylobacter Jejuni Infection and Anti Ganglioside GM1 Antibodies in Children with Guillain Barre Syndrome[J]. CJCP, 2003, 5(6): 533-536.
