OBJECTIVE: Hydrocephalus is one of the most common complications of neonatal intraventricular hemorrhage (IVH). In this study, the effect of serial lumbar puncture (LP) on severe neonatal IVH is evaluated. METHODS: The effects of serial LP on 30 neonates hospitalized with severe IVH at Xinhua hospital since 1993 was evaluated. Another 30 neonates with severe IVH who had not been treated for preventing post-IVH hydrocephalus were used as the control group. RESULTS: Of the 30 cases which received serial LP therapy, the cerebral ventricles of 25 cases stopped enlarging and shrank distinctly. The effective rate was 83.3% . The average age when serial LP therapy initiated was (15.0 ±13.5) days, the average treatment course was (16.9 ±12.9) days. The serial LP therapy was repeated (6.4±4.7) times. The avarage interval of LP was (2.9 ± 2.7) days and the average CSF volume removed was (6.7±1.6) ml. The average time of LP taking effect was (9.6 ± 5.5) days. Ten cases received diamox treatment during the course of serial LP. After 1 - 2 weeks' combined treatment, the enlarged ventricles of 8 cases returned to normal or remained steady. Eighteen of 25 ases were followed-up for (8.3±1.9) months. Their physical and mental development were normal. Cranialcerebral ultrasound examination found that the shapes of cerebral ventricles of 14 cases were normal and the cerebral ventricles of another 4 cases enlarged slightly. The treatment with removed CSF > 5 ml/ time or with a shorter interval of LP ( < 2 d) acheived better effect ( P < 0. 05 or 0. 01) . In the control group, the cerebral ventricles of 23 cases enlarged moderately or severely (6 of them complicated with hydrocephalus). CONCLUSIONS: Serial LP is a safe and effective method for severe neonatal IVH in preventing post-IVH hydrocephalus."/>
连续腰穿治疗新生儿重度脑室内出血的疗效评估(英文)
Abstract：OBJECTIVE: Hydrocephalus is one of the most common complications of neonatal intraventricular hemorrhage (IVH). In this study, the effect of serial lumbar puncture (LP) on severe neonatal IVH is evaluated. METHODS: The effects of serial LP on 30 neonates hospitalized with severe IVH at Xinhua hospital since 1993 was evaluated. Another 30 neonates with severe IVH who had not been treated for preventing post-IVH hydrocephalus were used as the control group. RESULTS: Of the 30 cases which received serial LP therapy, the cerebral ventricles of 25 cases stopped enlarging and shrank distinctly. The effective rate was 83.3% . The average age when serial LP therapy initiated was (15.0 ±13.5) days, the average treatment course was (16.9 ±12.9) days. The serial LP therapy was repeated (6.4±4.7) times. The avarage interval of LP was (2.9 ± 2.7) days and the average CSF volume removed was (6.7±1.6) ml. The average time of LP taking effect was (9.6 ± 5.5) days. Ten cases received diamox treatment during the course of serial LP. After 1 - 2 weeks' combined treatment, the enlarged ventricles of 8 cases returned to normal or remained steady. Eighteen of 25 ases were followed-up for (8.3±1.9) months. Their physical and mental development were normal. Cranialcerebral ultrasound examination found that the shapes of cerebral ventricles of 14 cases were normal and the cerebral ventricles of another 4 cases enlarged slightly. The treatment with removed CSF > 5 ml/ time or with a shorter interval of LP ( < 2 d) acheived better effect ( P < 0. 05 or 0. 01) . In the control group, the cerebral ventricles of 23 cases enlarged moderately or severely (6 of them complicated with hydrocephalus). CONCLUSIONS: Serial LP is a safe and effective method for severe neonatal IVH in preventing post-IVH hydrocephalus.
QIAN Ji-Hong,CHEN Hui-Jin,HUANG Jin-Ling et al. Effects of Serial Lumbar Puncture on Severe Intraventricular Hemorrhage of Neonates[J]. CJCP, 2003, 5(5): 407-411.
