兰州地区回族与汉族儿童维生素D受体基因多态性分布

黄新文, 宁淑敏, 尤玲, 陈永前

中国当代儿科杂志 ›› 2003, Vol. 5 ›› Issue (1) : 37-38.

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PDF(275 KB)
中国当代儿科杂志 ›› 2003, Vol. 5 ›› Issue (1) : 37-38.
论著

兰州地区回族与汉族儿童维生素D受体基因多态性分布

  • 黄新文,宁淑敏,尤玲,陈永前
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Distribution of Vitamin D Receptor Gene Polymorphism in Hui and Han Ethnic Children in Lanzhou Region

  • HUANG Xin-Wen, NING Shu-Min, YOU Ling, CHEN Yong-Qian
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摘要

目的:了解兰州地区回族与汉族儿童维生素D受体(VDR)基因多态性分布,探讨不同种族之间VDR基因型频率的分布。方法:利用限制性内切酶Bsm Ⅰ,采用聚合酶链反应限制性片段长度多态性技术(PCR-RFLP),对兰州地区回族健康儿童81例和汉族健康儿童169例VDR基因多态性进行检测。结果:发现在回族81例中,bb型57例(70.4%),Bb型22例(27.2%),BB型2例(2.5%);在汉族169例中,bb型154例(91.1%),Bb型12例(7.1%),BB型3例(1.8%)。结论:兰州地区回族VDR基因多态性分布与汉族相比存在显著性差异。

Abstract

OBJECTIVE: To investigate the distribution of vitamin D receptor (VDR) gene polymorphism in Hui and Han ethnic children in Lanzhou region and to study the difference between children of the two different ethnic groups. METHODS: VDR genotypes were assayed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 81 healthy Hui ethnic children and in 169 healthy Han ethnic children. RESULTS: Frequencies of bb, Bb and BB genotype were 70. 4% , 27. 2% and 2.5% respectively in the 81 Hui ethnic children and they were 91.1 % , 7.1% and 1.8% respectively in the 169 Han ethnic children. CONCLUSIONS: There is a significant difference in the frequency distribution of VDR genotype between Hui and Han ethnic children. [Chin J Contemp Pediatr, 2003, 5(1): 37-38]

关键词

维生素D受体 / 基因多态性 / 聚合酶链反应

Key words

Vitamin D receptor / Gene polymorphism / Polymerase chain reaction

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黄新文, 宁淑敏, 尤玲, 陈永前. 兰州地区回族与汉族儿童维生素D受体基因多态性分布[J]. 中国当代儿科杂志. 2003, 5(1): 37-38
HUANG Xin-Wen, NING Shu-Min, YOU Ling, CHEN Yong-Qian. Distribution of Vitamin D Receptor Gene Polymorphism in Hui and Han Ethnic Children in Lanzhou Region[J]. Chinese Journal of Contemporary Pediatrics. 2003, 5(1): 37-38
中图分类号: Q786   

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