OBJECTIVE: To investigate the effect of early intervention with naloxone, heparin and radix salviae miltrorrhizae (a Chinese patent medicine improving blood circulation) on brain damage in the newborn following severe perinatal asphyxia. METHODS: One hundred and eighty neonates with severe perinatal asphyxia were randomly assigned into four groups (45 cases each group): Group A received routine treatment (using cerebrolysin and citicoline); besides routine treatment, Group B, Group C and Group D were given naloxone, radix salviae miltrorrhizae and the combination of naloxone, heparin and radix salviae miltrorrhizae, respectively. The incidence of convulsion and the mortality were observed; the degree of hypoxic ischemic encephalopathy (HIE) was evaluated; and the Neonatal Behavioral Neurological Assessment (NBNA) was done in all groups. RESULTS: The incidence of convulsion and severe HIE was significantly lower ( 35.6% and 26.7% ) in Group D compared with that of Group A, B or C ( 66.7% , 44.4% , 53.3% ; 53.3% , 37.8% , 42.2% )(P< 0.05 ). The percentage of the cases whose NBNA marks were less than 35 at 7-8 d ( 25.6% ) and 12-14 d ( 14.0% ) after birth in Group D was much lower than that in Group A, B or C ( 74.3% , 50.0% , 47.5% ; 57.1% , 35.0% , 32.5% )(P< 0.05 ). The mortality of Group D was also lower. CONCLUSIONS: Besides routine treatment, combination of naloxone, heparin and radix salviae miltrorrhizae as early as possible after resuscitation can markedly reduce the degree of hypoxic ischemic brain damage."/>
早期药物干预对围生期重度窒息新生儿脑损伤程度的影响
Abstract：OBJECTIVE: To investigate the effect of early intervention with naloxone, heparin and radix salviae miltrorrhizae (a Chinese patent medicine improving blood circulation) on brain damage in the newborn following severe perinatal asphyxia. METHODS: One hundred and eighty neonates with severe perinatal asphyxia were randomly assigned into four groups (45 cases each group): Group A received routine treatment (using cerebrolysin and citicoline); besides routine treatment, Group B, Group C and Group D were given naloxone, radix salviae miltrorrhizae and the combination of naloxone, heparin and radix salviae miltrorrhizae, respectively. The incidence of convulsion and the mortality were observed; the degree of hypoxic ischemic encephalopathy (HIE) was evaluated; and the Neonatal Behavioral Neurological Assessment (NBNA) was done in all groups. RESULTS: The incidence of convulsion and severe HIE was significantly lower ( 35.6% and 26.7% ) in Group D compared with that of Group A, B or C ( 66.7% , 44.4% , 53.3% ; 53.3% , 37.8% , 42.2% )(P< 0.05 ). The percentage of the cases whose NBNA marks were less than 35 at 7-8 d ( 25.6% ) and 12-14 d ( 14.0% ) after birth in Group D was much lower than that in Group A, B or C ( 74.3% , 50.0% , 47.5% ; 57.1% , 35.0% , 32.5% )(P< 0.05 ). The mortality of Group D was also lower. CONCLUSIONS: Besides routine treatment, combination of naloxone, heparin and radix salviae miltrorrhizae as early as possible after resuscitation can markedly reduce the degree of hypoxic ischemic brain damage.
ZHOU Wei,LAI Jian-Pu,LV Hui et al. Effect of Early Medication Intervention on Neonatal Brain Damage Following Severe Perinatal Asphyxia[J]. CJCP, 2002, 4(6): 462-465.
