OBJECTIVE: To study the changes and clinical significance of circulating endothelial cells in childhood acute bacillary dysentery. METHODS: Thirty children with acute bacillary dysentery (treatment group), and 30 cases of viral enteritis (control group) were studied. The treatment group was further divided into two sub groups: treatment sub groupⅠ (8 cases with toxic bacillary dysentery) and treatment sub groupⅡ (22 cases with ordinary bacillary dysentery). The number of circulating endothelial cells (CEC) in the blood was determined by the flow cytometry on the 1st day and the 5th day of the disease. RESULTS: The CEC level of the treatment group on the 1st day ( 4.57 ± 0.69 ) was higher than that in the same group on the 5th day ( 1.06 ± 0.15 ), and higher than the control group on the 1st day ( 1.22 ± 0.23 ) and 5th day ( 1.18 ± 0.20 ) (P< 0.01 ). The CEC level of the treatment sub group Ⅰwas markedly higher than that in the treatment sub group Ⅱ on the 1st day [( 5.43 ± 0.50 ) vs ( 4.25 ± 0.44 )] (P< 0.05 ). There was no difference in the CEC level between the two treatment groups on the 5th day. CONCLUSIONS: CEC may be important in discerning children with acute bacillary dysentery, and be a pathologic target in making an early diagnosis and selecting effective treatments."/>
小儿急性细菌性痢疾血循环内皮细胞的变化和意义
摘要 目的：观察小儿急性细菌性痢疾时血循环内皮细胞(CEC)的变化和意义。方法：将患儿分为观察组(急性细菌性痢疾患儿30例)及对照组(病毒性肠炎30例)，其中观察组又分为观察组Ⅰ(中毒型8例)和观察组Ⅱ(普通型22例)。采用流式细胞仪检测患儿在发病第1天及第5天时的血循环内皮细胞(CEC)数。结果：观察组患儿第1天CEC水平(4.57±0.69)个/mm3高于该组第5天(1.06±0.15)个/mm3及对照组第1天(1.22±0.23)个/mm3、第5天(1.18±0.20)个/mm3 CEC水平，差异有显著性(P<0.01)。观察组Ⅰ第1天CEC水平(5.43±0.50)个/mm3，明显高于观察组Ⅱ第1天的CEC水平(4.25±0.44)，P<0.01；而二者第5天CEC水平(0.98±0.12 vs 1.10±1.15)差异无显著性(P>0.05)。结论：CEC可能对鉴别急性细菌性痢疾具有重要意义，并可能成为此类疾病早期诊断，选择积极治疗的重要指标。
Abstract：OBJECTIVE: To study the changes and clinical significance of circulating endothelial cells in childhood acute bacillary dysentery. METHODS: Thirty children with acute bacillary dysentery (treatment group), and 30 cases of viral enteritis (control group) were studied. The treatment group was further divided into two sub groups: treatment sub groupⅠ (8 cases with toxic bacillary dysentery) and treatment sub groupⅡ (22 cases with ordinary bacillary dysentery). The number of circulating endothelial cells (CEC) in the blood was determined by the flow cytometry on the 1st day and the 5th day of the disease. RESULTS: The CEC level of the treatment group on the 1st day ( 4.57 ± 0.69 ) was higher than that in the same group on the 5th day ( 1.06 ± 0.15 ), and higher than the control group on the 1st day ( 1.22 ± 0.23 ) and 5th day ( 1.18 ± 0.20 ) (P< 0.01 ). The CEC level of the treatment sub group Ⅰwas markedly higher than that in the treatment sub group Ⅱ on the 1st day [( 5.43 ± 0.50 ) vs ( 4.25 ± 0.44 )] (P< 0.05 ). There was no difference in the CEC level between the two treatment groups on the 5th day. CONCLUSIONS: CEC may be important in discerning children with acute bacillary dysentery, and be a pathologic target in making an early diagnosis and selecting effective treatments.
