RSV感染患儿外周血CD_4~*”CD_(45)RO~+CD_(45)RA~+表达变化的研究

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摘要目的：探讨下呼吸道感染呼吸道合胞病毒(RSV)患儿外周血辅助性T淋巴细胞(CD4)，原始T细胞(CD45RA+)，记忆性T细胞(CD45RO+)表达的变化。方法：用单克隆抗体免疫荧光标记，流式细胞仪检测30例RSV下呼吸道感染患儿急性期外周血单个核细胞(PBMCs)CD4+，CD45RA+细胞，其中11例同时检测CD45RO+细胞，同期检测9例年龄、性别无差异的健康儿为对照。结果：RSV下呼吸道感染组患儿CD4为(32.74±10.60)%，明显低于对照组(40.76±6.82)%，2组有显著性差异(P0.05)。结论：RSV感染急性期存在免疫功能紊乱，外周血CD4，CD45RO+下降，而CD45RA+明显增加，这可能是CD45RO+向呼吸道迁移的结果。

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	张艳敏
	雷春莲
	成革胜
	杨玉琮

关键词 ：呼吸道合胞病毒, 辅助性T细胞亚群, CD45, 儿童

Abstract：OBJECTIVE: To study the expression of CD4+ (helper T lymphocyte), CD45RA+ and CD45RO+ in PBMCs of infants with RSV LRTIs. METHODS: CD4+ and CD45RA+ were detected in 30 patients with RSV LRTIs and CD45RO+ in PBMCs was also assayed except for CD+4 and CD45RO+ in 11 of them with the flow cytometric analysis. Nine healthy children were used as the controls. RESULTS: In RSV infants, CD4+ cells ［(32.74±10.60)%］ decreased and CD45RA+ ［(80.65±10.35)%］ increased compared with the controls ［(40.76±6.82)% and (67.34±7.54)%, respectively］ (P<0.01). CD45RO+ cells also decreased, but not significantly. CONCLUSIONS: There is a disorder of immune function in PBMCs in infants with RSV.

Key words： RSV T help lymphocyte CD45 Child

PACS:

R373.1

引用本文:

张艳敏,雷春莲,成革胜等. RSV感染患儿外周血CD_4~*”CD_(45)RO~+CD_(45)RA~+表达变化的研究[J]. 中国当代儿科杂志, 2001, 3(3): 260-261.

ZHANG Yan-Min,LEI Chun-Lian,CHENG Ge-Sheng et al. Expression of CD45RA+ and CD45RO+ in PBMCs of Infants with RSV LRTIs[J]. CJCP, 2001, 3(3): 260-261.

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http://www.zgddek.com/CN/ 或 http://www.zgddek.com/CN/Y2001/V3/I3/260