Abstract：OBJECTIVE: To investigate the therapeutic effect of Duoxikang capsula (DXK) on hyperlipoidemia in children with the steroid sensitive nephrotic syndrome (SSNS). METHODS: Twenty SSNS children were randomly divided into a DXK treated group and a control group. DXK was then administered (45 mg/kg weight daily) in the DXK treated group and the same regular steroid therapeutic measurements were conducted in two groups of SSNS. Bloodlipoid compliments were determined, including total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoproteincholesterol (LDL-C) before the randomization, and again 2～3 weeks, 5～6 weeks, 8～10 weeks after the treatment. RESULTS: During the 2～3 weeks, levels of LDL-C ［(3.19±2.08) mmol and TC ［(6.42±2.04) mmol］ in the DXKtreated group were markedly lower than those in the control group ［(5.82±2.73) mmol, (10.0±4.75) mmol, respectively］ (both P<0.05). During the 5～6 weeks and 8～10 weeks, the level of LDL-C in the DXK treated group was also lower than that in the control group ［(2.83±1.50) mmol vs (4.94±2.04) mmol; (2.30±0.46) mmol vs (4.20±2.22) mmol, respectively. P<0.01 . CONCLUSIONS: DXK treatment reduced severe hyperlipoidemia, especially LDL-C in children with SSNS. It is suggested that DXK treatment may reduce the secondary renal injury in these children.
WANG Mo,LI Yong-Bai,LI Qiu et al. Reatment of the Steroid Sensitive Nephrotic Syndrome Complicated by Hyperlipoidemia in Children[J]. CJCP, 2001, 3(2): 141-143.
