Abstract：OBJECTIVE: To evaluate the therapeutic effect on children with acute idiopathic thrombocytopenic purpura (AITP) by intravenous immunoglobulin (IVIG) or dexmethasone (DEX). METHODS: Fortysix patients aged from 4 months to 14 years with AITP were randomized to receive IVIG or DEX, and we monitored the platelet count (Tc) and observed the side effects after each treatment. RESULTS: There was no difference in the lasting time of Tc≤20×109/L and the time when Tc increased to ≥50×109/L between the treatment of IVIG and DEX (P>0.05). But the percentage of patients with Tc≥50×109/L was higher in the IVIG group Ⅱ (88%) than in the DEX group (50%) after the 5 day treatment (P<0.05). CONCLUSIONS: We may choose IVIG to treat the patients with AITP complicated by severe mucomenbrane and organ bleeding, while we may use DEX if the patients have no complication.
DU Yue,XU Gang,HAO Liang-Chun. Therapeutic Effects of Immunoglobulin and Dexmethasone on Children with Acute Idiopathic Thromabocytopenic Purpura[J]. CJCP, 2001, 3(1): 39-40.
