目的 测定黄芩甙在兔感染性脑水肿模型血浆和脑脊液中的药代动力学参数和脑脊液渗透性。方法 采用高效液相色谱法（HPLC）同时测定血浆和脑脊液中黄芩甙浓度。结果 血浆黄芩甙的浓度-时间曲线下的面积（AUCp）每小时30.63±9.21 μg/ml，半衰期（t1/2p）2.19±0.42 h，峰浓度（Cmax p）56±7.6 μg/ml。黄芩甙在脑脊液浓度-时间曲线下的面积（AUCcsf）每小时10.29±5.6μg/ml，半衰期（t1/2csf）2.31±0.37h，峰浓度（Cmax csf）2.35±1.23 μg/ml，达峰时间（t max csf）2.33±0.4 h，比血浆达峰时间明显滞后。脑脊液和血浆浓度-时间曲线下面积之比（AUC csf /AUCp）达0.32（＞0.2）。结论 黄芩甙在兔感染性脑水肿模型脑脊液中具有较好的渗透性。

Objective To study the pharmacokinetics and cerebrospinal fluid penetration of baicalin in brain edema induced by pertussis bacilli in rabbits. Methods Baicalin concentrations of plasma and cerebrospinal fluid samples were determined by high-performance liquid chromatography. Results In plasma, area under the drug concentration-time curve (AUCp) was 30.63±9.21 μg/ml per hour, half-life (t 1/2p ) was 2.19±0.42 h, and time of maximum plasma concentration (Cmax p) was 56±7.6 μg/ml. In cerebrospinal fluid, AUCcsf was 10.29±5.6 μg/ml per hour, half-life (t 1/2csf ) was 2.31±0.37 h , maximum CSF concentration (Cmax csf) was 2.35±1.23 μg/ml, and time of maximum CSF concentration (tmax csf) was 2.33±0.4 h .The ratio of AUC in plasma and CSF (AUCcsf/AUCp) was 0.32 (>0.2). Conclusions There is a better CSF penetration of baicalin observed in infectious brain edema in rabbits.