Abstract：Objective To explore the mechanism and effect of baicalin (BC), tetramethy1pyrazine (TMPZ) and mannitol (MN) on infectious brain edema induced by pertussis bacilli (PB) in rabbits. Methods Epidural intracranial pressure (ICP) was monitored continuously by fiberoptic ICP monitor. The activity of phospholipase A 2 (PLA 2) in serum and CSF, brain water contents (WC), Evan′s blue (EB), Na + contents, and the concentrations of malondialdehy (MDA) and superoxide dismutase (SOD) were determined. Results The activity of PLA 2 in serum and CSF of both BC and TMPZ groups were significantly lower at 3 hours and 5 hours than those of PB and MN groups (P<0.05). WC, EB, Na + contents and MDA concentrations in left brain tissues of all treated groups were significantly lower compared with that of the PB group, but SOD activity in brain tissues of all treated groups were significantly higher than that of the PB group. All groups BC, TMPZ and MN could reduced the intracranial hypertension (ICH), the effect of BC was the strongest, that of TMPZ and MN in proper order. Conclusions Both BC and TMPZ could inhibit the activity of PLA 2 in serum and CSF, and reduce the brain edema and intracranial hypertension induced by PB in rabbits.
CHEN Guang-Fu,YU Pei-Lan,JIN Li-Ming et al. Effect of baicalin and tetramethylpyrazine on infectious brain edema and phospholipase A2 in rabbits[J]. CJCP, 1999, 1(3): 149-152.
