目的 探讨黄芩甙(BC)、川芎嗪(TMPZ)、甘露醇(MN)对兔百日咳菌液(PB)脑水肿的治疗作用及机理。方法 应用兔感染性脑水肿模型，用光导纤维颅连续监测硬膜外颅内压，测定血清及脑脊液(CSF)中磷脂酶A2 (PLA2)活性、脑组织含水量(WC)、伊文思蓝(EB)、钠含量及丙二醛(MDA)与超氧化物歧化酶(SOD)活性，观察黄芩甙、川芎嗪和甘露醇治疗对血清及CSF中PLA2活性的抑制作用以及与改善脑水肿的关系。结果 血清及CSF中PLA2活性BC组和TMPZ组明显低于PB组和MN组。脑组织含水量、伊文思蓝含量与钠含量：PB组较NS组明显增高，治疗各组均减少，依次为MN组>TMPZ组>BC组。3个治疗组均能降低MDA浓度，提高SOD活性和减轻颅内压增高。降颅内压的作用以BC最佳，依次为TMPZ，MN。结论 BC与TMPZ均可抑制PLA2活性和脂质过氧化，从而减轻脑水肿与降低颅内高压。

Objective To explore the mechanism and effect of baicalin (BC), tetramethy1pyrazine (TMPZ) and mannitol (MN) on infectious brain edema induced by pertussis bacilli (PB) in rabbits. Methods Epidural intracranial pressure (ICP) was monitored continuously by fiberoptic ICP monitor. The activity of phospholipase A 2 (PLA 2) in serum and CSF, brain water contents (WC), Evan′s blue (EB), Na + contents, and the concentrations of malondialdehy (MDA) and superoxide dismutase (SOD) were determined. Results The activity of PLA 2 in serum and CSF of both BC and TMPZ groups were significantly lower at 3 hours and 5 hours than those of PB and MN groups (P<0.05). WC, EB, Na + contents and MDA concentrations in left brain tissues of all treated groups were significantly lower compared with that of the PB group, but SOD activity in brain tissues of all treated groups were significantly higher than that of the PB group. All groups BC, TMPZ and MN could reduced the intracranial hypertension (ICH), the effect of BC was the strongest, that of TMPZ and MN in proper order. Conclusions Both BC and TMPZ could inhibit the activity of PLA 2 in serum and CSF, and reduce the brain edema and intracranial hypertension induced by PB in rabbits.