神经系统疾病儿童的血铅水平调查：单中心初步研究

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摘要目的：儿童铅中毒具有很大的潜在危害。慢性低水平铅暴露会导致学习障碍及行为问题，如腹痛，失眠，多动，生长发育落后，听力损失，上肢无力。该研究旨在调查神经系统疾病儿童的血铅水平，并与健康儿童作比较。方法：100名患有神经系统疾病的1~10岁儿童作为研究对象。100名年龄和性别匹配的健康儿童作为对照。采用火焰原子吸收光谱法检测血铅含量。结果：神经系统疾病组儿童的平均血铅含量显著高于对照组，差异有显著性 (113.2±47.5 μg/L vs 84.7±38.0 μg/L; P<0.01)。神经系统疾病组和对照组分别有44%和19%的儿童血铅超标（>100 μg/L）。结论：儿童血铅水平增高可能与神经系统疾病有关。建议对患神经系统疾病的儿童常规作血铅测定。［中国当代儿科杂志，2009，11（11）：873-876］

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	Touran MAHMOUDIAN
	Mohamadreza
	MODARESI
	Ali ZAREI
	Parinaz POURSAFA
	Roya KELISHADI

关键词 ：血铅, 神经系统疾病, 儿童

Abstract：OBJECTIVE: Lead poisoning is a potentially devastating problem among young children. Chronic low level lead exposure can lead to learning disabilities and behavior changes such as colic, insomnia, hyperactivity, impaired growth, hearing loss and upper extremity weakness. The purpose of this cross-sectional study was to determine the blood lead level in children with neurological disorders in comparison with healthy controls. METHODS: lead concentrations were measured by flame atomic absorption spectrometry in 100 children aged 1-10 years and suffering from various neurological disorders. One hundred age- and sex-matched healthy children served as controls. RESULTS: The mean blood lead concentration was higher in children with neurological disorders than in controls (113.2±47.5 μg/L vs 84.7±38.0 μg/L; P<0.01). Overall, 44% of children with neurological disorders and 19% of controls were found to have increased blood lead levels, i.e.>100 μg/L. CONCLUSIONS: An increase in blood lead level in children might be related to neurological disorders. The measurement of blood lead level might be included in diagnostic eveluation of children with neurological disorders.［Chin J Contemp Pediatr, 2009, 11 (11):873-876］

Key words： Blood Lead Neurological disorder Child

PACS:	R12
	R748

引用本文:

Touran MAHMOUDIAN,Mohamadreza,MODARESI等. 神经系统疾病儿童的血铅水平调查：单中心初步研究[J]. 中国当代儿科杂志, 2009, 11(12): 873-876.

Touran MAHMOUDIAN,Mohamadreza,MODARESI et al. Blood lead levels in children with neurological disorders: a single centre preliminary study[J]. CJCP, 2009, 11(12): 873-876.

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http://www.zgddek.com/CN/ 或 http://www.zgddek.com/CN/Y2009/V11/I12/873

	［1］Handley MA, Hall C, Sanford E, Diaz E, Gonzalez-Mendez E, Drace K. et al. Globalization, binational communities, and imported food risks: results of an outbreak investigation of lead poisoning in Monterey County, California［J］. Am J Public Health, 2007, 97(5):900-906.
	［2］Friedman JA. Six children with lead poisoning［J］. Am J Dis Child, 1991, 145 (6): 602.
	［3］Cohen SM. Lead poisoning: a summary of treatment and prevention［J］. Pediatr Nurs, 2001, 27(2):125-126, 129-130.
	［4］Mathee A, Rollin H, Levin J, Naik I. Lead in paint: three decades later and still a hazard for African children? ［J］. Environ Health Perspect, 2007, 115(3):321-322.
	［5］Canfield RL, Kreher DA, Cornwell C, Henderson CR Jr. Low-level lead exposure, executive functioning, and learning in early childhood［J］. Child Neuropsychol, 2003, 9(1):35-53.
	［6］Jusko TA, Henderson CR, Lanphear BP, Cory-Slechta DA, Parsons PJ, Canfield RL. Blood lead concentrations <10 microg/dL and child intelligence at 6 years of age［J］. Environ Health Perspect, 2008, 116(2):243-248.
	［7］Chen A, Cai B, Dietrich KN, Radcliffe J, Rogan WJ. Lead exposure, IQ, and behavior in urban 5-to 7-year-olds: does lead affect behavior only by lowering IQ? ［J］. Pediatrics, 2007, 119(3):e650-e658.
	［8］Markowitz M. Lead poisoning［M］. //Nelson Textbook of Pediatrics. 18th ed. Pennsylvania: Saunders, 2007,2913-2918.
	［9］Woolf AD, Goldman R, Bellinger DC. Update on the clinical management of childhood lead poisoning［J］. Pediatr Clin North Am, 2007, 54(2):271-294.
	［10］Nogar NS. Method for measuring lead concentrations in blood［P］. U.S pattern, 6248592, 2001-06-19.
	［11］CDC. Preventing lead poisoning in young children. Atlanta, GA: US Department of Health and Human Services, CDC［EB/OL］.
	［12］Soong WT, Chao KY, Jang CS, Wang JD. Long-term effect of increased lead absorption on the intelligence of children［J］. Arch Environ Health, 1999, 54(4):297-301.
	［13］Burns JM, Baghurst PA, Sawyer MG. Lifetime low-level exposure to environmental lead and children′s emotional and behavioral development at ages 11-13 years［J］.Am J Epidemiol, 1999,149(8):740-749.
	［14］Kumar A, Dey PK, Singla PN, Ambasht RS, Upadhyay SK . Blood lead level in children with neurological disorders［J］. J Trop Pediatr, 1998, 44(6):320-322.
	［15］Lalor G, Vutchkov M, Bryan S. Blood lead levels of Jamaican children islandwide［J］. 2007, 374(2-3):235-241.
	［16］Modarres R, Khosravi Dehkordi A. Daily air pollution time series analysis of Isfahan City［J］. Int J Environ Sci Tech, 2005, 2(13):259-267.
	［17］Kelishadi R, Mirghaffari N, Poursafa P, Gidding SS. Lifestyle and environmental factors associated with inflammation, oxidative stress and insulin resistance in children［J］. Atherosclerosis, 2009, 203(1):311-319.