N端脑利钠肽前体在新生儿缺氧缺血性心肌损伤中的变化

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摘要目的：探讨N端脑利钠肽前体(NT-proBNP)在缺氧缺血性脑病(HIE)合并心肌损伤患儿中的变化，为临床早期诊断及治疗提供理论依据。方法：选择我院收住的35例HIE患儿为研究对象(心肌损伤17例，非心肌损伤18例)，以20例正常新生儿为对照组，应用ELASA方法测定血浆NT-proBNP 水平。结果：①心肌损伤患儿NT-proBNP水平(338.8±76.2 fmol/mL) 显著高于非心肌损伤组(137.5±45.1 fmol/mL) 和对照组(113.7±53.6 fmol/mL), 均P<0.01。②轻、中、重度HIE组NT-proBNP水平分别为141.3±41.6、271.8±118.1和347.2±85.1 fmol/mL，中、重度HIE组显著高于对照组（P<0.01）；轻、中、重度HIE组间比较差异有显著性，P<0.05。③心肌损伤组急性期血浆NT-proBNP水平明显高于恢复期(338.8±76.2 fmol/mL vs 225.0±80.0 fmol/mL), P<0.01。结论：心肌损伤患儿急性期NT-proBNP水平升高。对HIE患儿检测血浆NT-proBNP有助于早期诊断心肌损伤，判断HIE病情。［中国当代儿科杂志，2009，11（12）：973-975］

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	张志玲
	林丽星
	安彩霞
	陶仲宾
	杨梅

关键词 ：缺氧缺血性脑病, 心肌损伤, N端脑利钠肽, 新生儿

Abstract：OBJECTIVE: To investigate the changes of N-terminal pro-brain natriuretic peptide (NT-proBNP) in neonates with hypoxic-ischemic encephalopathy (HIE) complicated by myocardial ischemic injury. METHODS: Thirty-five neonates with HIE (17 cases with concurrent myocardial injury and 18 cases without) were enrolled. Twenty healthy neonates were used as the control group. Plasma NT-proBNP levels were measured using enzyme immunoassay. RESULTS: The mean plasma NT-proBNP levels in patients with myocardial injury (338.8±76.2 fmol/mL) were significantly higher than those in patients with non-myocardial injury (137.5±45.1 fmol/mL) and in the control group (113.7±53.6 fmol/mL) (P<0.01). The NT-proBNP levels in mild, moderate and severe HIE neonates were 141.3±41.6, 271.8±118.1 and 347.2±85.1 fmol/mL, respectively. Compared with the control group, the NT-proBNP levels in the moderate and the severe HIE groups significantly increased (P<0.01). There were significant differences in the NT-proBNP level among the mild, moderate and severe HIE groups (P<0.05). In patients with myocardial injury, the NT-proBNP levels significantly decreased in the convalescent phase compared with those in the acute phase (225.0±80.0 fmol/mL vs 338.8±76.2 fmol/mL (P<0.01). CONCLUSIONS: Plasma NT-proBNP levels increase in neonates with HIE complicated by myocardial ischemic injury in the acute phase. Detection of NT-proBNP levels may be useful in the diagnosis of myocardial ischemic injury and the severity evaluation of HIE.［Chin J Contemp Pediatr, 2009, 11 (12):973-975］

Key words： Hypoxic-ischemic encephalopathy Myocardial injury NT-proBNP Neonate

PACS:

R722.1

引用本文:

张志玲,林丽星,安彩霞等. N端脑利钠肽前体在新生儿缺氧缺血性心肌损伤中的变化[J]. 中国当代儿科杂志, 2009, 11(12): 973-975.

ZHANG Zhi-Ling,LIN Li-Xing,AN Cai-Xia et al. Changes of N-terminal pro-brain natriuretic peptide in neonates with myocardial ischemic injury[J]. CJCP, 2009, 11(12): 973-975.

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http://www.zgddek.com/CN/ 或 http://www.zgddek.com/CN/Y2009/V11/I12/973

	［1］Mir TS, Marohn S, Laer S, Eiselt M, Grollmus O, Weil J. Plasma concentrations of N-terminal pro-brain natriuretic peptide in control children from the neonatal to adolescent period and in children with congestive heart failure［J］. Pediatrics, 2002, 110(6)：76-87.
	［2］武育蓉,陈树宝,孙锟,黄美蓉,张玉奇,陈笋.现有儿科心力衰竭诊断标准及脑利钠肽对先天性心脏病合并心力衰竭的诊断价值［J］.中华儿科杂志, 2006, 44(10)：728-732.
	［3］中华医学会儿科学分会新生儿学组.新生儿缺氧缺血性脑病诊断标准［J］.中国当代儿科杂志, 2005, 7(2)：97-98.
	［4］虞人杰,李黎,汤泽中,李涛,苏瑞杰,庞琳,等.新生儿窒息多脏器损害的临床研究［J］.中华儿科杂志, 1997, 35(3)：138-141.
	［5］邵肖梅.新生儿缺氧缺血性脑病的诊治进展及相关问题［J］.临床儿科杂志, 2007, 25(3)：179-182.
	［6］金汉珍,黄德珉,官希吉.实用新生儿学［M］.第3版.北京：人民卫生出版社, 2003, 600-603.
	［7］Holmgren D, Westerlind A, Lundberg PA, Wahlander H. Increased plasma levels of natriuretic peptide type B and A in children with congenital heart defects with left compared with right ventricular volume overload or pressure overload［J］. Clin Physiol Funct Imaging, 2005, 25(5)：263269.
	［8］Hall C. Essential biochemistry and physiology of (NT-pro) BNP［J］. Eur J Heart Fail, 2004, 6(3)：257-260.
	［9］Goetze JP, Christoffersen C, Perko M, Arendrup H, Rehfeld JF, Kastrup J, et al. Increased cardiac BNP expression associated with myocardial ischemia［J］. FASEB J, 2003, 17(9)：1105-1107.
	［10］Kragelund C, Gronning B, Kober L, Hildebrandt P, Steffensen R. N-terminal pro-B-type natriuretic peptide and long-term mortality in stable coronary heart disease［J］. N Engl J Med, 2005, 352(7)：666-675.
	［11］Heeschen C, Hamm CW, Mitrovic V, Lantelme NH, White HD. N-terminal pro-B-type natriuretic peptide levels for dynamic risk stratification of patients with acute coronary syndromes［J］. Circulation, 2004, 110(20)：3206-3212.