摘要 目的：观察益生菌制剂对低出生体重早产儿喂养不耐受的防治作用及其安全性。方法：将60例低出生体重早产儿随机分成益生菌治疗组和常规治疗组，每组30例，两组均治疗原发病，益生菌治疗组在治疗原发病的同时给予益生菌治疗(0.25 g, 每天两次)。比较两组喂养不耐受的发生率、恢复出生体重时间、达全胃肠道营养时间、住院时间；记录不良反应发生情况。结果：益生菌治疗组喂养不耐受的发生率较常规治疗组低(4% vs 14%，P<0.05)，恢复出生体重的时间较常规治疗组早（6.8±1.2 d vs 7.7±1.6 d，P<0.01），且达全胃肠道营养的时间较常规治疗组早（8.0±1.4 d vs 9.0±2.0 d，P<0.05）。益生菌用药中未见不良反应发生。结论：益生菌可降低低出生体重早产儿喂养不耐受的发生率，促进其体重增长，缩短其达全胃肠道营养的时间；且益生菌的应用是安全的。［中国当代儿科杂志，2010，12（9）：693-695］
Abstract：OBJECTIVE: To study the efficacy and safety of probiotics for the prevention of feeding intolerance in low birth weight (LBW) premature infants. METHODS: Sixty eligible LBW premature infants were randomly divided into probiotics and conventional treatment groups (n=30 each). Both groups received treatment of the primary disease. Additionally, the probiotics treatment group was administered with probiotics (0.25 g, twice daily). The incidence of feeding intolerance, the time to regain birth weight and to reach full enteral nutrition and the length of hospitalization were compared between the two groups. The occurrence of adverse reactions was recorded. RESULTS: The incidence of feeding intolerance in the probiotics treatment group was lower than that in the conventional treatment group (4% vs 14%; P<0.01). The time to regain birth weight (6.8±1.2 days vs 7.7±1.6 days; P<0.05) and the time to reach full enteral nutrition (8.0±1.4 days vs 9.0±2.0 days; P<0.05) in the probiotics treatment group were shorter than those in the conventional treatment group. No adverse reactions were observed in the probiotics treatment group. CONCLUSIONS: Probiotics can reduce the incidence of feeding intolerance in LBW premature infants, can promote weight gain and shorten the time to reach full enteral nutrition. The application of probiotics appears to be safe in LBW premature infants.［Chin J Contemp Pediatr, 2010, 12 (9):693-695］
HU Xiao-Yan,ZHOU Yu-Xin,XU Song-Zhou et al. Effects of probiotics on feeding intolerance in low birth weight premature infants[J]. CJCP, 2010, 12(09): 693-695.
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