Abstract：Objective To investigate the incidence and mortality rates of preterm infants and the main causes of death. Methods The basic information of preterm infants was collected from their medical records and admission/discharge records to analyze the incidence and mortality rates of preterm infants and the causes of their death. Results There were 76 812 neonates born in the Xuzhou Maternal and Child Health Hospital from January 2006 to December 2016, among whom 5585 (7.27%) were preterm infants. The incidence rate of preterm infants tended to increase over these years (P < 0.001). The overall mortality rate was 5.01% (280/5585), and the mortality rate tended to decrease over these years (P < 0.001). The mortality rate increased with the reductions in birth weight and gestational age (P < 0.001). The top four causes of death in preterm infants were respiratory distress syndrome (44.3%), severe asphyxia (12.9%), neonatal malformation (4.3%), and pulmonary hemorrhage (2.9%) respectively. With the increase in birth weight, there were significant reductions in the constituent ratios of death due to respiratory distress syndrome and severe asphyxia (P < 0.001). Conclusions The incidence rate of preterm infants tended to increase and their mortality rate tended to decrease from 2006 to 2016. The mortality rate of preterm infants is associated with gestational age and birth weight. Respiratory distress syndrome and severe asphyxia are the main causes of death in preterm infants.
YAN Jun-Mei,HUANG Hui,LI Qian-Qian et al. A single-center study on the incidence and mortality of preterm infants from 2006 to 2016[J]. CJCP, 2018, 20(5): 368-372.
Murray CJ, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010:a systematic analysis for the Global Burden of Disease Study 2010[J]. Lancet, 2012, 380(9859):2197-2223.
[2]
Howson CP, Kinney MV, McDougall L, et al. Born too soon:preterm birth matters[J]. Reprod Health, 2013, 10(Suppl 1):S1.
[3]
Galinsky R, Polglase GR, Hooper SB, et al. The consequences of chorioamnionitis:preterm birth and effects on development[J]. J Pregnancy, 2013:412831.
[4]
沈晓明,王卫平. 儿科学[M]. 第7版. 北京:人民卫生出版社, 2008:104.
[5]
Duryea EL, McIntire DD, Leveno KJ. The rate of preterm birth in the United States is affected by the method of gestational age assignment[J]. Am J Obstet Gynecol, 2015, 213(2):231.e1-e5.
Chen F, Bajwa NM, Rimensberger PC, et al. Thirteen-year mortality and morbidity in preterm infants in Switzerland[J]. Arch Dis Child Fetal Neonatal Ed, 2016, 101(5):F377-F383.
[9]
Hoseini BL, Sadati ZM, Rakhshani MH. Assessment of neonatal mortality in the Neonatal Intensive Care Unit in Sabzevar City for the period of 2006-2013[J]. Electron Physician, 2015, 7(7):1494-1499.
[10]
Ancel PY, Goffinet F; EPIPAGE-2 Writing Group, et al. Survival and morbidity of preterm children born at 22 through 34 weeks' gestation in France in 2011:results of the EPIPAGE-2 cohort study[J]. JAMA Pediatr, 2015, 169(3):230-208.
Shim JW, Jin HS, Bae CW. Changes in survival rate for verylow-birth-weight infants in Korea:comparison with other countries[J]. J Korean Med Sci, 2015, 30(Suppl 1):S25-S36.
[17]
Sweet DG, Carnielli V, Greisen G, et al. European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants-2013 update[J]. Neonatology, 2013, 103(4):353-368.
[18]
Sweet DG, Carnielli V, Greisen G, et al. European consensus guidelines on the management of respiratory distress syndrome -2016 update[J]. Neonatology, 2017, 111(2):107-125.
Golubnitschaja O, Yeghiazaryan K, Cebioglu M, et al. Birth asphyxia as the major complication in newborns:moving towards improved individual outcomes by prediction targeted prevention and tailored medical care[J]. EPMA J, 2011, 2(2):197-210.
Wyckoff MH, Aziz K, Escobedo MB, et al. Part 13:Neonatal Resuscitation:2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care[J]. Circulation, 2015, 132(18 Suppl 2):S543-S560.
