Relationship between serum estradiol levels in the early postnatal period and the occurrence of hyaline membrane disease and bronchopulmonary dysplasia in neonates
ZHANG Li-Juan, WANG Bin, LIU Guo-Sheng
Department of Pediatrics, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. Email: wangbin6556@126.com
Abstract：OBJECTIVE: This study examined the changes of serum levels of estradiol during the early postnatal period in neonates in order to investigate the possible relationship between the serum estradiol levels and the occurrence of pulmonary hyaline membrane disease (HMD) and bronchopulmonary dysplasia (BPD). METHODS: Fifty-nine premature infants with the gestational age between 26 and 32 weeks and 61 full-term infants with the gestational ages between 37 and 42 weeks were enrolled. Serum levels of estradiol were measured on postnatal days 1, 3 and 7. RESULTS: Serum levels of estradiol decreased rapidly after birth in both premature and term infants and there were significant differences among different postnatal ages groups. However, there were no significant differences in the serum estradiol levels between the premature and term groups on postnatal days 1, 3 and 7. Serum estradiol levels measured in premature infants with HMD were not statistically different from those in premature infants without HMD on all time points. Serum estradiol levels in premature infants with BPD were higher than those in premature infants without BPD on postnatal day 3, but there were no noticeable differences on postnatal days 1 and 7. CONCLUSIONS: Serum estradiol levels decline rapidly within 7 days after birth in both premature and term infants. Serum estradiol levels in the early postnatal period are not associated with the occurrence of HMD and BPD, suggesting that serum estradiol in the early postnatal period can not be used as a marker for predicting the development of HMD and BPD.［Chin J Contemp Pediatr, 2010, 12 (11):864-866］
ZHANG Li-Juan,WANG Bin,LIU Guo-Sheng. Relationship between serum estradiol levels in the early postnatal period and the occurrence of hyaline membrane disease and bronchopulmonary dysplasia in neonates[J]. CJCP, 2010, 12(11): 864-866.
［4］Jobe AH, Bancalari E. Bronchopulmonary dysplasia［J］. Am J Respir Crit Care Med, 2001,163(7): 1723-1729.
［5］Cunningham FG, Paul CM, Norman FG, Kenneth JL, Larry CG,Gary DV, et al. 威廉姆斯产科学［M］.第20版.西安：世界图书出版公司, 2001: 137-143.
［6］Tulchinsky D, Hobel J, Yeage E. Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy(Ⅰ): normal pregnancy［J］. Am J Obstet Gynecol, 1972, 112(8): 1095-1100.
［8］Massaro D, Massaro GD. Estrogen regulates pulmonary alveolar formation, loss, and regeneration in mice［J］. Am J Physiol Lung Cell Mol Physiol, 2004, 287(6): L1154-L1159.
［9］Andreas T, Michael E. Prenatal estrogen and progesterone deprivation impairs alveolar formation and fluid clearance in newborn piglets［J］. Pediatr Res, 2006, 60(1): 60-64.
［11］Shanklin D, Wolfson S. Aqueous estrogens in the management of respiratory distress syndrome［J］. J Reprod Med, 1970, 5(2): 53-71.
［12］Herbst A, Ulfelder H, Poskanzer D. Adenocarcinoma of the vagina.Association of maternal stilbestrol therapy with tumor appearance in young women［J］. N Engl J Med, 1971, 284(5): 878-881.
［13］Trotter A, Maier L, Kron M, Pohlandt F. Effects of postnatal oestradiol and progesterone replacement on bronchopulmonary dysplasia in extremely preterm infants［J］. Arch Dis Child Fetal Neonatal Ed, 2007, 92(2): F94-98.
