Abstract：OBJECTIVE: To study the association of alanine aminotransferase (ALT) with overweight or obesity in children. METHODS: A total of 2889 healthy children and 702 overweight or obese children aged from 7 to 18 years who had received a physical examination were enrolled. Height, body weight, waist circumference, and blood pressure were measured, and the biochemical indicators including blood glucose, blood lipids, ALT, and insulin were detected. The insulin resistance index were calculated. RESULTS: The ALT level was significantly higher in boys than in girls. Along with the increase of BMI, the ALT level increased in the normal, overweight, and obese groups in both boys and girls. ALT was correlated with BMI, waist circumference, triglyceride, and insulin resistance index. Among the overweight or obese children, the boys with the increased ALT level had higher BMI, waist circumference, blood pressure, triglyceride, low density lipoprotein and insulin resistance index than the boys with normal ALT level (P<0.05); the girls with the increased ALT level had higher waist circumference, blood pressure and insulin resistance index and lower high density lipoprotein than the girls with normal ALT level (P<0.05). CONCLUSIONS: ALT is correlated with overweight and obesity and metabolic disorders caused by overweight and obesity such as dyslipidemia and insulin resistance.
FAN Xin,CHEN Shao-Ke,TANG Qing et al. Relationship between alanine aminotransferase and overweight or obesity in children[J]. CJCP, 2011, 13(12): 951-954.
［2］Goessling W, Massaro JM, Vasan RS, D′Agostino RB Sr, Ellison RC, Fox CS. Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease［J］. Gastroenterology, 2008, 135(6): 1935-1944.
［3］Sattar N, McConnachie A, Ford I, Gaw A, Cleland SJ, Forouhi NG, et al. Serial metabolic measurements and conversion to type 2 diabetes in the west of Scotland coronary prevention study: specific elevations in alanine aminotransferase and triglycerides suggest hepatic fat accumulation as a potential contributing factor［J］. Diabetes, 2007, 56(4): 984-991.
［5］Esteghamati A, Jamali A, Khalilzadeh O, Noshad S, Khalili M, Zandieh A,et al. Metabolic syndrome is linked to a mild elevation in liver aminotransferases in diabetic patients with undetectable non-alcoholic fatty liver disease by ultrasound［J］.Diabetol Met Syndrome, 2010, 11(2):65.
［6］Steinvil A, Shapira I, Ben-Bassat OK, Cohen M, Vered Y, Berliner S,et al. The association of higher levels of within-normal-limits liver enzymes and the prevalence of the metabolic syndrome［J］. Cardiovasc Diabetol, 2010, 6(15): 9-30.
［7］Kang HS, Um SH, Seo YS, An H, Lee KG, Hyun JJ,et al.Healthy range for serum ALT and the clinical significance of "unhealthy" normal ALT levels in the Korean population［J］.Gastroenterol Hepatol, 2011, 26(2): 292-299.
［10］Zimmet P, Alberti G, Kaufman F, Tajima N, Silink M, Arslanian S, et al. International Diabetes Federation Task Force on Epidemiology and Prevention of Diabetes. The metabolic syndrome in children and adolescents［J］.Lancet, 2007, 369(9579): 2059-2061.
［13］Kariv R, Leshno M, Beth-Or A, Strul H, Blendis L, Kokia E, et al. Re-evaluation of serum alanine aminotransferase upper normal limit and its modulating factors in a large-scale population study［J］. Liver Int, 2006, 26(4): 445-450.
［14］England K, Thorne C, Pembrey L, Tovo PA, Newell ML. Age-and sex-related reference ranges of alanine aminotransferase levels in children: European paediatric HCV network［J］.Pediatr Gastroenterol Nutr, 2009, 49(1): 71-77.
［15］Strauss RS, Barlow SE, Dietz WH. Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents［J］. J Pediatr, 2000, 136(6): 727-733.
