Abstract:OBJECTIVE: To study the risk factors for recurrent pneumonia in children without underlying diseases. METHODS: A case-control study was conducted in 106 children with recurrent pneumonia (case group) and 106 age, gender- and weight-matched children with pneumonia but no recurrence (control group). The children in both groups had no underlying disease. The risk factors for recurrent pneumonia were investigated by the Chi-Square analysis and the multivariate logistic regression model. RESULTS: The Chi-Square analysis showed that the percentages with the history of wheezing, allergy (food or medicine) and eczema and the percentage of transient neutropenia in the case group were significantly higher than those in the control group. The multivariate logistic regression analysis showed that the wheezing history (OR=13.387, 95% CI: 5.541-32.343), allergic history (food or medicine) (OR=4.267, 95% CI: 2.081-8.751) and transient neutropenia (OR=3.606, 95% CI: 1.806-7.202) were the independent risk factors of recurrent pneumonia. ConclusionsThe wheezing history, allergic history and transient neutropenia may increase the risk of recurrence of pneumonia in pneumonic children without underlying diseases.
[9]Heffelfinger JD, Davis TE, Gebrian B, Bordeau R, Schwartz B, Dowell SF. Evaluation of children with recurrent pneumonia diagnosed by World Health Organization criteria[J]. Pediatr Infect Dis J, 2002, 21(2): 108-112.
[10]Talbot TR, Hartert TV, Mitchel E, Halasa NB, Arbogast PG, Poehling KA, et al. Asthma as a risk factor for invasive pneumococcal disease[J]. N Engl J Med, 2005, 352(20): 2082-2090.
[11]Almirall J, Bolibar I, Serra-Prat M, Roig J, Hospital I, Carandell E, et al. New evidence of risk factors for community-acquired pneumonia: a population-based study[J]. Eur Respir J, 2008, 31(6): 1274-1284.
[12]Jung JA, Kita H, Yawn BP, Boyce TG, Yoo KH, McGree ME, et al. Increased risk of serious pneumococcal disease in patients with atopic conditions other than asthma[J]. J Allergy Clin Immunol, 2010, 125(1): 217-221.
[13]Bohme M, Lannero E, Wickman M, Nordvall SL, Wahlgren CF. Atopic dermatitis and concomitant disease patterns in children up to two years of age[J]. Acta Derm Venereol, 2002, 82(2): 98-103.
[14]Frankowska J, Kamer B, Trznadel-Budzko E, Rotsztejn H. The retrospective evaluation of pneumonia and bronchitis cases in infants and small children with atopic dermatitis in the practice of a family doctor -personal observations[J]. Adv Med Sci, 2010, 55(2): 250-253.
[15]Pitzurra L, Bellocchio S, Nocentini A, Bonifazi P, Scardazza R, Gallucci L, et al. Antifungal immune reactivity in nasal polyposis[J]. Infect Immun, 2004, 72(12): 7275-7281.
[18]Chu HW, Thaikoottathil J, Rino JG, Zhang G, Wu Q, Moss T, et al. Function and regulation of SPLUNC1 protein in Mycoplasma infection and allergic inflammation[J]. J Immunol, 2007, 179(6): 3995-4002.
[19]Arkwright PD, Patel L, Moran A, Haeney MR, Ewing CI, David TJ. Atopic eczema is associated with delayed maturation of the antibody response to pneumococcal vaccine[J]. Clin Exp Immunol, 2000, 122(1): 16-19.
[20]Don M, Fasoli L, Gregorutti V, Pisa F, Valent F, Prodan M, et al. Recurrent respiratory infections and phagocytosis in childhood[J]. Pediatr Int, 2007, 49(1): 40-47.