先天性心脏病患儿血浆脑钠肽水平与左心功能的关系

张鹤; 李玖军

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中国当代儿科杂志 ›› 2012, Vol. 14 ›› Issue (1) : 42-44.

论著·临床研究

先天性心脏病患儿血浆脑钠肽水平与左心功能的关系

张鹤，李玖军

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Correlation between the blood serum BNP level and the left cardiac function in children with congenital heart disease

ZHANG He, LI Jiu-Jun

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摘要

目的：探讨先天性心脏病（先心病）患儿血浆脑钠肽（BNP）水平与左心功能的相关性及其临床意义。方法：回顾性分析41例先心病患儿的临床资料，根据有无合并充血性心力衰竭（CHF）将其分为2组：一组为合并CHF组（n=21），另一组为无合并CHF组（n=20）。用化学发光免疫分析法测定血浆BNP水平，超声心动图测定左室射血分数(LVEF)。结果：①先心病合并CHF组患儿血浆BNP水平为1353（926，2978）pg/mL，显著高于先心病无合并CHF组［149（75，242）pg/mL］（P<0.01)；先心病合并CHF组患儿LVEF为60（53，65）%，显著低于先心病无合并CHF组68（64，72）%（P<0.01)。②先心病患儿血浆BNP水平与LVEF呈显著负相关(r=-0.652，P<0.01)。结论：BNP可作为反映左心功能受损的敏感指标，与心功能状态有明显相关性，其检测对先心病合并CHF患儿左心功能的判断具有重要意义。

Abstract

OBJECTIVE: To study the correlation between the blood serum brain natriuretic peptide (BNP) level and the left cardiac function in children with congenital heart disease (CHD). METHODS: The clinical data of 41 CHD children were retrospectively analyzed. Patients were divided into two groups based on the existence of congestive heart failure (CHF): CHD+CHF (n=21) and CHD alone (n=20). The blood serum BNP level was determined using chemiluminescence immunoassay, and the left ventricular ejection fraction (LVEF) was measured with echocardiogram. RESULTS: The serum BNP level was 1353 pg/mL (range: 926-2978) in the CHD+CHF group, which was significantly higher than in the CHD alone group［149 pg/mL (range: 75-242)］(P<0.01). The LVEF was 60% (range: 53%-65%) in the CHD+CHF group, which was significantly lower than in the CHD alone group［68% (range: 64%-72%)］(P<0.01). The serum BNP level showed a negative correlation with the LVEF level (r=-0.652, P<0.01). CONCLUSIONS: The blood serum BNP level is related to the cardiac function. For children with severe CHD+CHF, serum BNP level can be used as a sensitive indicator for evaluating cardiac function damage.

导出引用

张鹤，李玖军. 先天性心脏病患儿血浆脑钠肽水平与左心功能的关系[J]. 中国当代儿科杂志. 2012, 14(1): 42-44

ZHANG He, LI Jiu-Jun. Correlation between the blood serum BNP level and the left cardiac function in children with congenital heart disease[J]. Chinese Journal of Contemporary Pediatrics. 2012, 14(1): 42-44

中图分类号： R725.4

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