Abstract：To evaluate left ventricular function in newborn infants of mothers with gestational diabetes mellitus (GDM). METHODS: Forty newborn infants of mother with GDM (GDM group) and forty normal newborn infants (control group) were enrolled in this study. Two-dimensional speckle tracking imaging was used to measure interventricular septal thickness, posterior left ventricular wall thickness and left ventricular ejection fraction in both groups. Left ventricular rotation and torsion were evaluated for all participants. RESULTS: Interventricular septal thickness in the GDM group was much higher than in the control group (0.45±0.06 mm vs 0.34±0.05 mm; P0.05). Peak subendocardial rotation, peak subepicardial rotation, peak bulk rotation and peak mural torsion were higher in the GDM group than in the control group (P<0.05). CONCLUSIONS: Cardiac function may be impaired in newborn infants of mothers with GDM, with changes in left ventricular shape and abnormalities of left ventricular rotation and torsion. However, infants have a normal ventricular blood ejection under the cardiac compensation. Two-dimensional speckle tracking imaging technique can be used for early detection of left ventricular function.
LIAO Wei-Qiang,ZHOU Huai-Yuan,CHEN Guan-Chun et al. Left ventricular function in newborn infants of mothers with gestational diabetes mellitus[J]. CJCP, 2012, 14(08): 575-577.
［5］Veille JC, Sivakoff M, Hanson R, Fanaroff AA. Interventricular septal thickness in fetuses of diabetic mothers ［J］. Obstet Gynecol, 1992, 79(1): 51-54.
［6］Kozák-Bárány A, Jokinen E, Kero P, Tuominen J, Ronnemaa T, Valimaki I. Impaired left ventricular diastolic function in newborn infants of mothers with pregestational or gestational diabetes with good glycemic control［J］. Early Hum Dev, 2004, 77(1-2): 13-22.
［7］Reller MD, Kaplan S. Hypertrophic cardiomyopathy in infants of diabetic mothers: an update［J］. Am J Perinatal, 1988, 5(4): 353-358.
［8］Gutgesell HP, Speer ME, Rosenberg HS. Characterization of the cardiomyophthy in infants of diabetic mothers［J］. Circulation, 1980, 61(2): 441-450.
［9］Chung J, Abraszewski P, Yu X, Liu W, Krainik AJ, Ashford M, et al. Paradoxical increase in ventricular torsion and systolic torsion rate in type 1 diabetic patients under tight glycemic control［J］. J Am Coll Cardiol, 2006, 47(2): 384-390.
