早产儿生后早期血清降钙素原生理变化规律的研究

doi:10.7499/j.issn.1008-8830.2013.02.001

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摘要目的：探讨生后不同时间和不同胎龄的早产儿血清降钙素原（PCT）生理变化规律。方法：无感染新生儿217例，其中足月儿115 例，早产儿102例，后者依据胎龄分为3个亚组：30~32周（30例）、33~34周（35例）、35~36周（37例），分别研究其生后0~12 h、13~24 h、25~36 h、37~48 h、49~72 h、73~96 h、97~120 h、121~144 h PCT水平变化规律。结果：新生儿生后随着时间推移，PCT逐渐升高，24 h左右达高峰，其后逐渐下降，生后96 h左右降至儿童正常值。早产儿组PCT峰值晚于足月儿组，约在生后36 h出现，此后缓慢下降，96 h左右降至和足月儿数据相当。30~32周早产儿生后PCT数值维持低浓度水平，37~48 h逐渐升高，升高时间晚于33~34周及35~36周早产儿。结论：新生儿在生后早期PCT有一个先增高后下降的动态变化过程，其中早产儿分泌高峰要迟于足月儿。32周以前早产儿生后36 h之内PCT水平较低。

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	刘云峰
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关键词 ：降钙素原, 生理变化, 胎龄, 早产儿

Abstract：OBJECTIVE: To investigate serum procalcitonin (PCT) concentrations in premature infants with different gestational ages at different times after birth. METHODS: A total of 217 neonates without infection, including 102 premature infants and 115 full-term infants, were enrolled in this study. The premature infants were further divided by gestational age into three subgroups: 30-32 weeks (n=30), 33-34 weeks (n=35) and 35-36 weeks (n=37). All the infants were studied to evaluate serum PCT concentrations at 0-12, 13-24, 25-36, 37-48, 49-72, 73-96, 97-120 and 121-144 hours after birth. RESULTS: In the newborns, serum PCT concentrations increased gradually after birth, reached peak values at about 24 hours after birth, and then gradually declined and dropped to normal values for children at about 96 hours after birth. In the premature infants, serum PCT concentrations reached peak values at about 36 hours after birth, later than in the full-term infants, then declined slowly and dropped to levels similar to the full-term infants at 96 hours after birth. Serum PCT concentrations in the 30-32 week subgroup remained at low levels after birth, and increased gradually, later than in other premature infants, at 37-48 hours after birth. CONCLUSIONS: Early after birth, neonates have a changing serum PCT concentration, increasing first and then decreasing. Peak serum PCT levels appear later in premature infants than in full-term infants. Serum PCT concentrations of premature infants with a gestational age of under 32 weeks remain at relatively low levels within 36 hours after birth.

Key words： Procalcitonin Physiological change Gestational age Premature infant

引用本文:

刘云峰,童笑梅,郑方圆等. 早产儿生后早期血清降钙素原生理变化规律的研究[J]. 中国当代儿科杂志, 2013, 15(2): 81-84.

LIU Yun-Feng,TONG Xiao-Mei,ZHENG Fang-Yuan et al. Physiological changes in serum procalcitonin concentrations in premature infants early after birth[J]. CJCP, 2013, 15(2): 81-84.

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