Abstract：OBJECTIVE: To investigate changes in serum complement, immunoglobulins and lymphocyte subsets in children with common and severe bronchial pneumonia, and the role of immune function testing in bronchial pneumonia. METHODS: Twenty children with common bronchial pneumonia, 20 with severe bronchial pneumonia and 20 healthy children (as controls) were enrolled in this study. Immunization rate scattering turbidimetry and six-color flow cytometry were used to detect changes in serum levels of IgA, IgG and IgM, complement C3 and C4 and CD3+, CD4+, CD8+, CD16+, CD56+ and CD19+ cells. RESULTS: The IgA levels of children with common and severe pneumonia were significantly lower than in the control group (P0.05). Compared with the controls, the children with severe pneumonia showed significantly lower CD4+ and CD3+ counts (P0.05). CONCLUSIONS: Immune dysfunction exists in children with bronchial pneumonia, especially those with severe pneumonia. Changes in immune function are correlated with the severity of pneumonia. Immune function testing in children with pneumonia has important clinical significance.
ZHU Xiao-Hua,CHEN Qiang,KE Jiang-Wei et al. Clinical analysis of immune function changes in children with bronchial pneumonia[J]. CJCP, 2013, 15(3): 175-178.
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