Abstract：OBJECTIVE: To investigate the species and percentage changes of pathogens in blood cultures from the pediatric hematology ward, and to analyze the drug resistance of main pathogens and the risk factors for positive blood culture (sepsis). METHODS: A retrospective analysis was performed to analyze the species and drug sensitivity of the pathogens isolated from 2358 blood cultures from the pediatric hematology ward of the West China Second University Hospital between 2008 and 2011, as well as the related clinical data. RESULTS: A total of 110 strains of pathogens were isolated, with Escherichia coli (16 strains), Pseudomonas aeruginosa (12 strains) and Staphylococcus epidermidis (8 strains) being the most common ones. From 2008 to 2011, the percentage of Gram-positive bacteria decreased, while the percentage of Gram-negative bacteria increased. The detection rates of methicillin-resistant coagulase-negative Staphylococci and methicillin-resistant Staphylococcus aureus were 69% and 43% respectively, but both were sensitive to vancomycin. The detection rates of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and ESBL-producing Klebsiella pneumoniae were 69% and 62% respectively, but both were sensitive to imipenem and meropenem. Malignant tumor was a risk factor for positive blood culture (OR=3.564, P<0.05). CONCLUSIONS: A wide range of pathogens are responsible for bloodstream infection in the pediatric hematology ward and the percentages of bacteria are changing; these pathogens have a high drug resistance rate. Malignant tumor is a risk factor for positive blood culture in the pediatric hematology ward.
KUANG Ling-Han,JIANG Yong-Mei,HU Zheng-Qiang et al. Species and drug resistance of pathogens in blood cultures from the pediatric hematology ward[J]. CJCP, 2013, 15(4): 259-263.
［4］Urrea M, Rives S, Cruz O, Navarro A,Garcia JJ,Estella J. Nosocomial infections among pediatric hematology /oncology patients: results of a prospect incidence study［J］. Am J Infect Control, 2004, 32(4): 205-208.
［5］Paulus SC, van Saene HKF, Hems worth S, Paulus SC, van Saene HK, et al. A prospective study of septicemia on a pediatric oncology unit: a three-year experience at the Royal Liverpool Children′s Hospital, Alder Hey, UK［J］. Euro J Cancer, 2005, 41(14): 2132-2140.
［6］Melvin P, Weinstein J. Blood culture contamination: persisting problems and partial progress［J］.Clin Microbial, 2003, 41(6): 2275-2278.
［8］Fortun J, Sanz MA, Madero L, Lopez J, de la Torre J, Jarque I, et al. Update on bacteremia in oncology and hematology［J］. Enferm Infect Microbial Clin, 2011, 29(4): 48-53.
